吗啉_MSDS_用途_密度_吗啉CAS号【110-91-8】

【用途一】
促进剂NOBS的主要原料,有作分析试剂及树脂、蜡类、虫胶等的溶剂 ,用于生产硫酸钠.水玻璃和群青等。还用于制造玻璃.造纸.洗涤剂.肥皂.染料.合成纤维.制革.医药和陶瓷等行业。分析试剂，如氮的测定，脱水剂。
【用途二】
用作医药、橡胶促进剂及荧光增白剂的原料
【用途三】
用作分析试剂及树脂、蜡类、酪朊、虫胶及多种染料的溶剂
【用途四】
吗啉是杀菌剂烯酰吗啉和氟吗啉及有机磷杀虫剂茂硫磷的中间体。
【用途五】
主要用于橡胶硫化促进剂的生产，还用于表面活性剂、纺织印染助剂、医药、农药的合成。吗啉还用作顺丁二烯聚合用催化剂、腐蚀抑制剂、光学漂白剂，本品也是染料，树脂、蜡、早胶、干酪素等的溶剂。目前，世界吗啉产量为3-4万t/a。吗啉的盐类也被广泛使用，吗啉盐酸盐（10024-89-2）等是有机合成的中间体；吗啉脂肪酸盐可作水果或瓜果类蔬菜表皮的被膜剂，可适当抑制基呼吸作用，防止水分的挥发及表皮的萎缩。
【用途六】
1,4-氧氮六环（110-91-8）主要应用于生产橡胶促进剂、合成病毒灵、布烙芬、咳必定等多种药物，在油漆、农药、增白剂、溶剂等方面也有广泛用途。还可用于制造N-甲基吗啉、N-乙基吗啉等多种中间体。

[ 密度 ]:
0.9±0.1 g/cm3

[ 沸点 ]:
128.9±0.0 °C at 760 mmHg

[ 熔点 ]:
-5 °C

[ 分子式 ]:
C₄H₉NO

[ 分子量 ]:
87.120

[ 闪点 ]:
35.6±0.0 °C

[ 精确质量 ]:
87.068413

[ PSA ]:
21.26000

[ LogP ]:
-1.08

[ 外观性状 ]:
无色油状液体，有氨味。

[ 蒸汽密度 ]:
3 (vs air)

[ 蒸汽压 ]:
10.4±0.2 mmHg at 25°C

[ 折射率 ]:
1.415

[ 储存条件 ]:
Store at R.T.

[ 稳定性 ]:
Stable. Flammable. Incompatible with strong oxidizing agents, strong acids, acid chlorides, acid anhydrides. Hygroscopic.

[ 水溶解性 ]:
MISCIBLE

[ 凝固点 ]:
-4.9℃

详细MSDS(安全技术说明书)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QD6475000

CHEMICAL NAME :: Morpholine

CAS REGISTRY NUMBER :: 110-91-8

BEILSTEIN REFERENCE NO. :: 0102549

LAST UPDATED :: 199712

DATA ITEMS CITED :: 57

MOLECULAR FORMULA :: C4-H9-N-O

MOLECULAR WEIGHT :: 87.14

WISWESSER LINE NOTATION :: T6M DOTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1450 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8000 ppm/8H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 525 mg/kg

TOXIC EFFECTS :: Behavioral - sleep Behavioral - somnolence (general depressed activity)

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1320 mg/m3/2H

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - lacrimation Behavioral - ataxia Lungs, Thorax, or Respiration - cyanosis

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 413 mg/kg

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 458 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 500 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Gastrointestinal - ulceration or bleeding from stomach Gastrointestinal - ulceration or bleeding from small intestine

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 1220 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 12000 mg/m3

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 24 gm/kg/30D-I

TOXIC EFFECTS :: Gastrointestinal - necrotic changes Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Related to Chronic Data - death

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 70 mg/m3/4H/17W-I

TOXIC EFFECTS :: Vascular - BP lowering not characterized in autonomic section Blood - changes in leukocyte (WBC) count

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 250 ppm/6H/13W-I

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 9 gm/kg/10D-I

TOXIC EFFECTS :: Liver - fatty liver degeneration Skin and Appendages - primary irritation (after topical exposure) Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 13500 mg/kg/30D-I

TOXIC EFFECTS :: Gastrointestinal - necrotic changes Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Related to Chronic Data - death

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 70 mg/m3/4H/17W-I

TOXIC EFFECTS :: Liver - liver function tests impaired Kidney, Ureter, Bladder - other changes in urine composition

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 27 gm/kg/30D-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in both tubules and glomeruli Skin and Appendages - primary irritation (after topical exposure) Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2560 mg/kg/Y-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - bronchiogenic carcinoma Liver - tumors

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

REFERENCE :: EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0779-0294 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 71 mg/m3 (20 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 47,199,1989 IARC Cancer Review:Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 47,199,1989 TOXICOLOGY REVIEW JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 8,707,1989 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 20 ppm (70 mg/m3) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,175,1971 OSHA PEL (Gen Indu):8H TWA 20 ppm (70 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 20 ppm (70 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 20 ppm (70 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 20 ppm (70 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 20 ppm (70 mg/m3);STEL 30 ppm (105 mg/m3);Skin JAN 1993 OEL-BELGIUM:TWA 20 ppm (71 mg/m3);STEL 30 ppm (107 mg/m3);Skin JAN 1993 OEL-DENMARK:TWA 20 ppm (70 mg/m3);Skin JAN 1993 OEL-FINLAND:TWA 20 ppm (70 mg/m3);STEL 30 ppm (105 mg/m3);Skin JAN 1993 OEL-FRANCE:TWA 20 ppm (70 mg/m3);STEL 30 ppm (105 mg/m3) JAN 1993 OEL-GERMANY:TWA 20 ppm (70 mg/m3);Skin JAN 1993 OEL-HUNGARY:STEL 10 mg/m3;Skin JAN 1993 OEL-THE NETHERLANDS:TWA 20 ppm (70 mg/m3);Skin JAN 1993 OEL-THE PHILIPPINES:TWA 20 ppm (70 mg/m3);Skin JAN 1993 OEL-RUSSIA:TWA 0.5 mg/m3;STEL 1.5 mg/m3;Skin JAN 1993 OEL-SWEDEN:TWA 20 ppm (70 mg/m3);STEL 30 ppm (110 mg/m3);Skin JAN 1993 OEL-SWITZERLAND:TWA 20 ppm (70 mg/m3);STEL 40 ppm;Skin JAN 1993 OEL-UNITED KINGDOM:TWA 20 ppm (70 mg/m3);STEL 30 ppm;Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO MORPHOLINE-air:10H TWA 20 ppm (Sk);STEL 30 ppm (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 48910 No. of Facilities: 20431 (estimated) No. of Industries: 132 No. of Occupations: 82 No. of Employees: 122734 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 48910 No. of Facilities: 13767 (estimated) No. of Industries: 133 No. of Occupations: 105 No. of Employees: 214367 (estimated) No. of Female Employees: 65146 (estimated)

[ 符号 ]:

GHS02, GHS05, GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H226-H302-H311 + H331-H314

[ 警示性声明 ]:
P210-P280-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338-P370 + P378

[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
C:Corrosive

[ 风险声明 (欧洲) ]:
R10;R20/21/22;R34

[ 安全声明 (欧洲) ]:
S23-S36-S45

[ 危险品运输编码 ]:
UN 2054 8/PG 1

[ WGK德国 ]:
3

[ RTECS号 ]:
QD6475000

[ 包装等级 ]:
I

[ 危险类别 ]:
8

[ 海关编码 ]:
2934999090

详细合成路线

吗啉上游产品

吗啉下游产品

1.由二乙醇胺经硫酸脱水环合而得。将二乙醇胺加入水反应锅内，在60℃以下滴加硫酸，加毕，升温于185-195℃，保温30min。冷至60℃以下，滴加氢氧化钠液至pH=11，冷却，过滤，滤液精馏，收集130℃以下馏分，精吗啉含量可达99.5%以上。该法原料易得，目前已成为世界生产吗啉的主要方法。由二噁烷与氨气相催化反应而可制得吗啉。

2.由二乙醇胺在硫酸存在下脱水环合而制得。将二乙醇胺加入反应锅内，在60℃以下滴加H₂SO₄，加毕升温至185～195℃，保温30min，冷却至60℃，滴加NaOH溶液，使pH＝11，冷却过滤，滤液精馏，收集130℃以下馏分即为吗啉。
也可用二乙二醇和氨在催化剂存在和压力下制得吗啉。该方法原料易得，成为目前世界上生产吗啉的主要方法。

精制方法：将吗啉与金属钠一起回流1小时，在干燥氮气流下常压蒸馏精制。或用无水硫酸钙干燥后分馏。也可以将吗啉制成草酸盐，用60%%乙醇重结晶2次，加入浓氢氧化钾水溶液使吗啉游离出来，分离后用固体氢氧化钾干燥，再用金属钠干燥，然后分馏。

3.由二甘醇与氨在氢气和镍催化剂存在下于30～40MPa大气压和150～400℃温度下反应制得。或者由二乙醇胺与过量的浓盐酸（或浓硫酸）作用制得。

4.在酸性环境下使二乙醇胺闭环就能制成吗啉，然后通过精馏提纯。

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Synthesis and antitumor activities of some new N1-(flavon-6-yl)amidrazone derivatives.

Arch. Pharm. (Weinheim) 347(6) , 415-22, (2014)

A new series of N1-(flavon-6-yl)amidrazones were synthesized by reacting the hydrazonoyl chloride derived from 6-aminoflavone with the appropriate sec-cyclic amines. The antitumor activities of these ...

Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds.

Bioorg. Med. Chem. 15 , 6943-55, (2007)

A set of 116 structurally very diverse compounds, mainly drugs, was characterized by 1630 molecular descriptors. The biological property modelled in this study was the transdermal permeability coeffic...

The c-MET/PI3K signaling is associated with cancer resistance to doxorubicin and photodynamic therapy by elevating BCRP/ABCG2 expression.

Mol. Pharmacol. 87(3) , 465-76, (2015)

Overexpression of BCRP/ABCG2, a xenobiotic efflux transporter, is associated with anticancer drug resistance in tumors. Proto-oncogene c-MET induces cancer cell proliferation, motility, and survival, ...

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公司名：上海吉至生化科技有限公司

区域：上海市奉贤区

价格：
￥58.0/500ml

联系人：刘佳

产品详情：吗啉

公司名：上海源溪生物科技有限公司

区域：上海市浦东新区

价格：
￥需询单/1g

联系人：赖经理

产品详情：Morpholine

公司名：上海阿拉丁生化科技股份有限公司

区域：上海市浦东新区

价格：
￥需询单/1mg ￥需询单/1g ￥需询单/1g ￥需询单/1g

联系人：阿拉丁李高志

产品详情：吗啉

公司名：济南创世化工有限公司

区域：济南市天桥区

价格：
￥需询单/25kg

联系人：严玲玲

产品详情：吗啉

公司名：山东金悦源新材料有限公司

区域：济南市天桥区

价格：
￥2000.0/200kg ￥10000.0/1ton

联系人：王思兵

产品详情：吗啉

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详细MSDS(安全技术说明书)

吗啉毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

吗啉安全信息

吗啉合成路线

详细合成路线

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