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异阿魏酸

异阿魏酸用途

反式异芥酸(反式-3-羟基-4-甲氧基肉桂酸)是一种从佛罗里达铁线莲的根中分离出来的芳香酸。反式异芥酸具有抗炎活性[1]。反式异戊酸通过诱导Nrf2依赖的血红素加氧酶-1(HO-1)[2]抑制NO和PGE2的产生。

异阿魏酸名称

[ CAS 号 ]:
25522-33-2

[ 中文名 ]:
异阿魏酸

[ 英文名 ]:
Isoferulic acid

[英文别名 ]:

2-Propenoic acid, 3-(3-hydroxy-4-methoxyphenyl)-
(E)-3-(3-hydroxy-4-methoxyphenyl)prop-2-enoic acid
3-(3-Hydroxy-4-methoxyphenyl)acrylic acid
Isoferulic acid
EINECS 247-071-6

异阿魏酸生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 免疫及炎症 >> 一氧化氮合酶

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 前列腺素受体

研究领域 >> 炎症/免疫

[ 靶点 ]

Human Endogenous Metabolite

[参考文献]

[1]. Kai-Hui Sun, et al. A new indole-type alkaloid from the roots of Clematis florida var. plena. Nat Prod Res. 2019 Oct;33(20):2925-2931.

[2]. Matharage Gayani Dilshara, et al. Downregulation of NO and PGE2 in LPS-stimulated BV2 microglial cells by trans-isoferulic acid via suppression of PI3K/Akt-dependent NF-κB and activation of Nrf2-mediated HO-1. Int Immunopharmacol. 2014 Jan;18(1):203-11.

异阿魏酸物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
410.2±35.0 °C at 760 mmHg

[ 分子式 ]:
C₁₀H₁₀O₄

[ 分子量 ]:
194.184

[ 闪点 ]:
167.6±19.4 °C

[ 精确质量 ]:
194.057907

[ PSA ]:
66.76000

[ LogP ]:
1.56

[ 蒸汽压 ]:
0.0±1.0 mmHg at 25°C

[ 折射率 ]:
1.627

[ 储存条件 ]:
2-8°C

异阿魏酸MSDS

详细MSDS(安全技术说明书)

异阿魏酸安全信息

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
NONH for all modes of transport

异阿魏酸文献

Development of a targeted method for twenty-three metabolites related to polyphenol gut microbial metabolism in biological samples, using SPE and UHPLC-ESI-MS/MS.

Talanta 128 , 221-30, (2014)

An increasing number of studies have concerned the profiling of polyphenol microbial metabolites, especially in urine or plasma, but only a few have regarded their accurate quantification. This study ...

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