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依鲁卡因

依鲁卡因用途

Elucaine 是蕈毒碱型乙酰胆碱受体 (mAChR) 拮抗剂,具有抗溃疡功效。

依鲁卡因名称

[ CAS 号 ]:
25314-87-8

[ 中文名 ]:
依鲁卡因

[ 英文名 ]:
Elucaine

[英文别名 ]:

Elucaina [INN-Spanish]
Elucaine
2-Diethylamino-1-phenylethyl benzoate
benzoic acid-(2-diethylamino-1-phenyl-ethyl ester)
Elucaine [USAN:INN]
Elucainum [INN-Latin]

依鲁卡因生物活性

[ 描述 ]:

Elucaine 是蕈毒碱型乙酰胆碱受体 (mAChR) 拮抗剂,具有抗溃疡功效。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 由mAChR

信号通路 >> 神经信号通路 >> mAChR

研究领域 >> 其他

[参考文献]

[1]. Rango Dietrich, et al. Pharmaceutical preparation comprising an active dispersed on a matrix. US 7175854 B2

[相关活性小分子]

依鲁卡因物理化学性质

[ 密度 ]:
1.067g/cm3

[ 沸点 ]:
411.5ºC at 760 mmHg

[ 分子式 ]:
C₁₉H₂₃NO₂

[ 分子量 ]:
297.39100

[ 闪点 ]:
133.9ºC

[ 精确质量 ]:
297.17300

[ PSA ]:
29.54000

[ LogP ]:
3.92650

[ 蒸汽压 ]:
5.54E-07mmHg at 25°C

[ 折射率 ]:
1.554

[ 储存条件 ]:
2-8℃

依鲁卡因毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DG8555000

CHEMICAL NAME :: Benzoic acid, 2-(diethylamino)-1-phenylethyl ester

CAS REGISTRY NUMBER :: 25314-87-8

BEILSTEIN REFERENCE NO. :: 2220826

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C19-H23-N-O2

MOLECULAR WEIGHT :: 297.43

WISWESSER LINE NOTATION :: 2N2&1YR&OVR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 892 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 47,96,1934

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 27 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 47,96,1934

依鲁卡因安全信息

[ 海关编码 ]:
2922199090

依鲁卡因合成路线

详细合成路线

依鲁卡因上下游产品

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依鲁卡因下游产品

依鲁卡因海关

[ 海关编码 ]: 2922199090

[ 中文概述 ]:
2922199090. 其他氨基醇及其醚，酯和它们的盐（但含一种以上含氧基的除外）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ Summary ]:
2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%