25314-87-8

• 常用中文名：依鲁卡因
• 常用英文名：Elucaine
• CAS号：25314-87-8
• 分子式：C₁₉H₂₃NO₂
• 分子量：297.39100
• 相关类别： 原料药 Anesthetic Agents Local anesthetics
• 发布时间：2018-05-04 08:00:00
• 更新时间：2024-01-02 17:19:00
• Elucaine 是蕈毒碱型乙酰胆碱受体 (mAChR) 拮抗剂,具有抗溃疡功效。

名称

• 中文名: 依鲁卡因
• 英文名: [2-(diethylamino)-1-phenylethyl] benzoate
• 英文别名: Elucaina [INN-Spanish]; Elucaine; 2-Diethylamino-1-phenylethyl benzoate; Benzoesaeure-(2-diaethylamino-1-phenyl-aethylester); benzoic acid-(2-diethylamino-1-phenyl-ethyl ester); Elucaine [USAN:INN]; Elucainum [INN-Latin]

物化性质

• 密度: 1.067g/cm3
• 沸点: 411.5ºC at 760 mmHg
• 分子式: C₁₉H₂₃NO₂
• 分子量: 297.39100
• 闪点: 133.9ºC
• 精确质量: 297.17300
• PSA: 29.54000
• LogP: 3.92650
• 蒸汽压: 5.54E-07mmHg at 25°C
• 折射率: 1.554
• 储存条件: 2-8℃

生物活性

• 描述: Elucaine 是蕈毒碱型乙酰胆碱受体 (mAChR) 拮抗剂,具有抗溃疡功效。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 由mAChR
  信号通路 >> 神经信号通路 >> mAChR
  研究领域 >> 其他
• 参考文献:

  [1]. Rango Dietrich, et al. Pharmaceutical preparation comprising an active dispersed on a matrix. US 7175854 B2

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : DG8555000 CHEMICAL NAME : Benzoic acid, 2-(diethylamino)-1-phenylethyl ester CAS REGISTRY NUMBER : 25314-87-8 BEILSTEIN REFERENCE NO. : 2220826 LAST UPDATED : 199612 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C19-H23-N-O2 MOLECULAR WEIGHT : 297.43 WISWESSER LINE NOTATION : 2N2&1YR&OVR HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 892 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 47,96,1934 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 27 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 47,96,1934

安全

• 海关编码: 2922199090

合成路线

4249-64-3 ~% 25314-87-8

文献：Bogatkov,S.V.; Cherkasova,E.M. J. Gen. Chem. USSR (Engl. Transl.), 1969 , vol. 39, p. 1861 - 1871,1823 - 1831

4249-64-3 98-88-4 ~% 25314-87-8

文献：Bogatkov,S.V.; Cherkasova,E.M. J. Gen. Chem. USSR (Engl. Transl.), 1969 , vol. 39, p. 1861 - 1871,1823 - 1831

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海关

海关编码	2922199090
中文概述	2922199090. 其他氨基醇及其醚，酯和它们的盐（但含一种以上含氧基的除外）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装
Summary	2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%