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酒石酸艾芬地尔

酒石酸艾芬地尔用途

Ifenprodil tartrate 是 NMDA受体拮抗剂,选择性抑制含NR2B亚基受体。

酒石酸艾芬地尔名称

[ CAS 号 ]:
23210-58-4

[ 中文名 ]:
酒石酸艾芬地尔

[ 英文名 ]:
ifenprodil tartrate

[中文别名 ]:

抗坏血酸钠.维丙钠

[英文别名 ]:

Ifenprodil Tartrate
Ifenprodil (+)-tartrate salt
Ifenprodil (tartrate)

酒石酸艾芬地尔生物活性

[ 描述 ]:

Ifenprodil tartrate 是 NMDA受体拮抗剂,选择性抑制含NR2B亚基受体。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> iGluR

信号通路 >> 神经信号通路 >> iGluR

研究领域 >> 神经疾病

[参考文献]

[1]. Gotti B, et al. Ifenprodil and SL 82.0715 as cerebral anti-ischemic agents. I. Evidence for efficacy in models of focal cerebral ischemia. J Pharmacol Exp Ther. 1988 Dec;247(3):1211-21.

[2]. Reynolds IJ, et al. Ifenprodil is a novel type of N-methyl-D-aspartate receptor antagonist: interaction with polyamines. Mol Pharmacol. 1989 Nov;36(5):758-65.

[3]. Schoemaker H, et al. Binding of [3H]ifenprodil, a novel NMDA antagonist, to a polyamine-sensitive site in the rat cerebral cortex. Eur J Pharmacol. 1990 Feb 6;176(2):249-50.

[4]. Shalaby IA, et al. Neuroprotective effects of the N-methyl-D-aspartate receptor antagonists ifenprodil and SL-82,0715 on hippocampal cells in culture. J Pharmacol Exp Ther. 1992 Feb;260(2):925-32.

[相关活性小分子]

酒石酸艾芬地尔物理化学性质

[ 沸点 ]:
493.5ºC at 760mmHg

[ 熔点 ]:
178-180ºC

[ 分子式 ]:
C₂₁H₂₇NO_2.1/₂C₄H₆O₆

[ 分子量 ]:
400.49

[ 闪点 ]:
248.7ºC

[ PSA ]:
158.76000

[ LogP ]:
1.58410

[ 蒸汽压 ]:
0mmHg at 25°C

[ 储存条件 ]:
Refrigerator

酒石酸艾芬地尔安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H312-H315-H319-H332-H335

[ 警示性声明 ]:
P261-P280-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R20/21/22;R36/37/38

[ 安全声明 (欧洲) ]:
22-26-36-36/37

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

酒石酸艾芬地尔文献

Hippocampal hyperexcitability underlies enhanced fear memories in TgNTRK3, a panic disorder mouse model.

J. Neurosci. 33(38) , 15259-71, (2013)

Panic attacks are a hallmark in panic disorder (PAND). During the panic attack, a strong association with the surrounding context is established suggesting that the hippocampus may be critically invol...

Double dissociation of the requirement for GluN2B- and GluN2A-containing NMDA receptors in the destabilization and restabilization of a reconsolidating memory.

J. Neurosci. 33(3) , 1109-15, (2013)

Signaling at NMDA receptors (NMDARs) is known to be important for memory reconsolidation, but while most studies show that NMDAR antagonists prevent memory restabilization and produce amnesia, others ...

Effect of NMDA NR2B antagonist on neuropathic pain in two spinal cord injury models.

Pain 153 , 1022-1029, (2012)

N-Methyl-d-aspartate (NMDA) receptors are thought to play an important role in the processes of central sensitization and pathogenesis of neuropathic pain, particularly after spinal cord injury (SCI)....

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