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伐地那非

伐地那非用途

Vardenafil是PDE5抑制剂,可作用于勃起功能障碍。

伐地那非作用

起效时间快，15至30分钟之内见效。副作用小，但因个体的差异，仍有不足2%的人会略感轻微头痛。溶于水和乙醇的特性，是目前做壮阳酒类、软胶囊及口服液的理想原料，持续时间可达6小时以上。

伐地那非名称

[ CAS 号 ]:
224785-90-4

[ 中文名 ]:
盐酸瓦地那非三水合物

[ 英文名 ]:
Vardenafil

[中文别名 ]:

[英文别名 ]:

Vardenafil (INN)
Vivanza
Vardenafil hydrochloride trihydrate
[14C]-Vardenafil
Vardenafil HCl Trihydrate
vardenafil
Levitra (TN)

伐地那非生物活性

[ 描述 ]:

Vardenafil是PDE5抑制剂,可作用于勃起功能障碍。

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> 磷酸二酯酶(PDE)

研究领域 >> 内分泌

[参考文献]

[1]. Saenz de Tejada, I., et al., The phosphodiesterase inhibitory selectivity and the in vitro and in vivo potency of the new PDE5 inhibitor vardenafil. Int J Impot Res, 2001. 13(5): p. 282-90.

[2]. Goldstein, I., et al., Vardenafil, a new phosphodiesterase type 5 inhibitor, in the treatment of erectile dysfunction in men with diabetes: a multicenter double-blind placebo-controlled fixed-dose study. Diabetes Care, 2003. 26(3): p. 777-83.

[相关活性小分子]

伐地那非物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
692.2ºC at 760mmHg

[ 熔点 ]:
214-216ºC

[ 分子式 ]:
C₂₃H₃₂N₆O₄S

[ 分子量 ]:
488.60

[ 闪点 ]:
372.5ºC

[ PSA ]:
121.28000

[ LogP ]:
2.65

[ 外观性状 ]:
白色结晶粉末

[ 蒸汽压 ]:
5.17E-19mmHg at 25°C

[ 折射率 ]:
1.656

[ 储存条件 ]:
?20°C

伐地那非安全信息

[ 符号 ]:

GHS02, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H302 + H312 + H332-H319

[ 警示性声明 ]:
P210-P261-P302 + P352 + P312-P304 + P340 + P312-P337 + P313-P403 + P235

[ 危害码 (欧洲) ]:
F,Xn

[ 风险声明 (欧洲) ]:
11-20/21/22-36

[ 安全声明 (欧洲) ]:
16-36/37

[ 危险品运输编码 ]:
UN1230 - class 3 - PG 2 - Methanol, solution

伐地那非合成路线

详细合成路线

伐地那非上下游产品

伐地那非上游产品

伐地那非下游产品

伐地那非文献

Improvement of exercise capacity in monocrotaline-induced pulmonary hypertension by the phosphodiesterase-5 inhibitor Vardenafil.

Respir. Physiol. Neurobiol. 186(1) , 61-4, (2013)

Vardenafil, a phosphodiesterase-5 inhibitor, is approved for the therapy of erectile dysfunction. However, in contrast to Sildenafil and Tadalafil, little is known about its effects on pulmonary hyper...

SOP conservative (medical and mechanical) treatment of erectile dysfunction.

J. Sex. Med. 10(1) , 130-71, (2013)

Erectile dysfunction (ED) is the most frequently treated male sexual dysfunction worldwide. ED is a chronic condition that exerts a negative impact on male self-esteem and nearly all life domains incl...

High inter-individual variability of vardenafil pharmacokinetics in patients with pulmonary hypertension.

Eur. J. Clin. Pharmacol. 69(2) , 197-207, (2013)

To evaluate the pharmacokinetic parameters of a single oral dose of vardenafil in patients with pulmonary hypertension (PH).Sixteen patients with PH received vardenafil in single oral doses (20, 10 or...

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