Caerulomycin A.

Caerulomycin A.用途

Caerulomycin A (Cerulomycin; Caerulomycin) 是一种抗真菌 (antifungal) 化合物,能够诱导 T 细胞的产生。Caerulomycin A 能够抑制 IFN-γ 诱导的 STAT1 通路,从而增强 TGF-β-Smad3 信号通路。具有抗真菌和抗细菌活性,可用于自身免疫病的研究。

Caerulomycin A.名称

[ CAS 号 ]:
21802-37-9

[ 中文名 ]:
Caerulomycin A.

[ 英文名 ]:
Caerulomycin A

[英文别名 ]:

CERULOMYCIN
(E)-4-methoxy-2,2'-bipyridyl-6-aldoxime
CAERULOMYCIN A
4-Methoxy-2,2'-bipyridine-6-carbaldehyde (E)-oxime
4-Methoxy-[2,2']bipyridyl-6-carbaldehyd-(E)-oxim
Caerulomycin,Cerulomycin
4-methoxy-[2,2']bipyridinyl-6-carbaldehyde oxime
4-methoxy-[2,2']bipyridyl-6-carbaldehyde-(E)-oxime
Caerulomycin A
CAERULOMYCIN

Caerulomycin A.生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 真菌

研究领域 >> 炎症/免疫

[ 靶点 ]

Antifungal[1] TGF-β-Smad3[1]

[参考文献]

[1]. Gurram RK, et al. Caerulomycin A enhances transforming growth factor-β (TGF-β)-Smad3 protein signaling by suppressing interferon-γ (IFN-γ)-signal transducer and activator of transcription 1 (STAT1) protein signaling to expand regulatory T cells (Tregs). J Biol Chem. 2014 Jun 20;289(25):17515-28.

Caerulomycin A.物理化学性质

[ 密度 ]:
1.23g/cm3

[ 沸点 ]:
400.4ºC at 760mmHg

[ 分子式 ]:
C₁₂H₁₁N₃O₂

[ 分子量 ]:
229.23500

[ 闪点 ]:
195.9ºC

[ 精确质量 ]:
229.08500

[ PSA ]:
67.60000

[ LogP ]:
1.96030

[ 储存条件 ]:
2-8℃

Caerulomycin A.MSDS

Caerulomycin A.安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H315-H319

[ 警示性声明 ]:
P301 + P310-P305 + P351 + P338

[ 危险品运输编码 ]:
UN 2811 6.1 / PGIII

[ 海关编码 ]:
2933399090

Caerulomycin A.合成路线

Caerulomycin A.上下游产品

Caerulomycin A.上游产品

Caerulomycin A.下游产品

Caerulomycin A.海关

[ 海关编码 ]: 2933399090

[ 中文概述 ]:
2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Caerulomycin A.文献

[Development of a genetic modification system for caerulomycin producer Actinoalloteichus sp. WH1-2216-6].

Wei Sheng Wu Xue Bao 51(8) , 1032-41, (2011)

In order to enable the caerulomyicn biosynthetic study by in vivo gene disruptions, it is crucial to develop a genetic modification system for the producer Actinoalloteichus sp. WH1-2216-6.The spore g...

Total synthesis of caerulomycin C via the halogen dance reaction.

Org. Lett. 4(14) , 2385-8, (2002)

[reaction: see text] The total synthesis of caerulomycin C is described. Key steps in this synthesis utilize 1,2-, 1,3-, and 1,4-halogen dance reactions for the functionalization of the pyridine ring.

Caerulomycin, an antifungal antibiotic with marked in vitro and in vivo activity against Entamoeba histolytica.

Z. Parasitenkd. 70(5) , 569-73, (1984)

The anti-amoebic action of the bipyridyl antibiotic caerulomycin was assessed in vitro and in vivo using various strains of Entamoeba histolytica from polyxenic, axenic and monoxenic cultures. Minimum...

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