Nω-硝基-L-精氨酸

Nω-硝基-L-精氨酸用途

Nitroarginine, or Nω-nitro-L-arginine, is a nitro derivative of the amino acid arginine. It is an inhibitor of nitric oxide synthase and hence a vaso-constrictor and coronary constrictor. As such, it finds widespread use as a biochemical tool in the study of nitric oxide and its biological effects. Nitroarginine has been used in research studying coronary constriction, in the presence of midazolam vasodilatation was unaffected by nitroarginine. Nitroarginine is currently in clinical trials for treating patients with advanced solid tumors.

Nω-硝基-L-精氨酸名称

[ CAS 号 ]:
2149-70-4

[ 中文名 ]:
N'-硝基-L-精氨酸

[ 英文名 ]:
H-Arg(NO2)-OH

[中文别名 ]:

[英文别名 ]:

(S)-2-Amino-5-(3-nitroguanidino)pentanoic acid
L-Ornithine, N-[(E)-imino(nitroamino)methyl]-
ARG(NO2)
L-NNA
N-ω-NITRO-L-ARGININE
L-NOARG
Nω-Nitro-L-arginine
(S)-2-Aminobut-3-enoic acid
H-Arg(NO2)-OH
L-Ornithine, N5-(imino(nitroamino)methyl)-

Nω-硝基-L-精氨酸物理化学性质

[ 密度 ]:
1.7±0.1 g/cm3

[ 沸点 ]:
462.4±55.0 °C at 760 mmHg

[ 熔点 ]:
257 °C (dec.)(lit.)

[ 分子式 ]:
C₆H₁₃N₅O₄

[ 分子量 ]:
219.199

[ 闪点 ]:
233.5±31.5 °C

[ 精确质量 ]:
219.096756

[ PSA ]:
157.05000

[ LogP ]:
-0.79

[ 外观性状 ]:
白色至灰白色固体

[ 蒸汽压 ]:
0.0±2.4 mmHg at 25°C

[ 折射率 ]:
1.638

[ 储存条件 ]:
室温

Nω-硝基-L-精氨酸MSDS

详细MSDS(安全技术说明书)

Nω-硝基-L-精氨酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

Nω-硝基-L-精氨酸合成路线

详细合成路线

Nω-硝基-L-精氨酸上下游产品

Nω-硝基-L-精氨酸上游产品

Nω-硝基-L-精氨酸下游产品

Nω-硝基-L-精氨酸文献

Role of Telokin in Regulating Murine Gastric Fundus Smooth Muscle Tension.

PLoS ONE 10 , e0134876, (2015)

Telokin phosphorylation by cyclic GMP-dependent protein kinase facilitates smooth muscle relaxation. In this study we examined the relaxation of gastric fundus smooth muscles from basal tone, or pre-c...

Network analysis of immunotherapy-induced regressing tumours identifies novel synergistic drug combinations.

Sci. Rep. 5 , 12298, (2015)

Cancer immunotherapy has shown impressive results, but most patients do not respond. We hypothesized that the effector response in the tumour could be visualized as a complex network of interacting ge...

Evidence for the gastric cytoprotective effect of centrally injected agmatine.

Brain Res. Bull. 108 , 51-9, (2014)

Agmatine (decarboxylated arginine) exerts cytoprotective action in several tissues, such as in the brain, heart or kidneys, but there is still controversy over the effects of agmatine on the gastric m...

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