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L-精氨酸盐酸盐

L-精氨酸盐酸盐用途

L-Arginine盐酸盐为合成一氧化氮的氮供体,是血管扩张剂。

L-精氨酸盐酸盐名称

[ CAS 号 ]:
1119-34-2

[ 中文名 ]:
L-精氨酸盐酸盐

[ 英文名 ]:
L-Arginine hydrochloride

[中文别名 ]:

[英文别名 ]:

(+)-L-arginine hydrochloride
Arginine, hydrochloride, L-
levargin
L-Arginine HCl
L-(+)-Arginine monohydrochloride
L-Arginine hydrochloride
L-ARG HCL
L-Arginine hydrochloride (1:1)
2-Amino-5-guanidinovalericacidmonohydrochloride
anhydrous L-arginine monohydrochloride

L-精氨酸盐酸盐生物活性

[ 描述 ]:

L-Arginine盐酸盐为合成一氧化氮的氮供体,是血管扩张剂。

[ 相关类别 ]:

信号通路 >> 免疫及炎症 >> 一氧化氮合酶

研究领域 >> 其他

天然产物 >> 其他

[参考文献]

[1]. Tapiero H, et al. I. Arginine. Biomed Pharmacother. 2002 Nov;56(9):439-45.

[2]. Bakker J, et al. Administration of the nitric oxide synthase inhibitor NG-methyl-L-arginine hydrochloride (546C88) by intravenous infusion for up to 72 hours can promote the resolution of shock in patients with severe sepsis: results of a randomized, double-blind, placebo-controlled multicenter study (study no. 144-002). Crit Care Med. 2004 Jan;32(1):1-12.

[3]. Yamada M, et al. Endothelial nitric oxide synthase-dependent cerebral blood flow augmentation by L-arginine after chronic statin treatment. J Cereb Blood Flow Metab. 2000 Apr;20(4):709-17.

[相关活性小分子]

L-精氨酸盐酸盐物理化学性质

[ 密度 ]:
1.42

[ 沸点 ]:
409.1ºC at 760 mmHg

[ 熔点 ]:
226-230 °C(lit.)

[ 分子式 ]:
C₆H₁₅ClN₄O₂

[ 分子量 ]:
210.662

[ 闪点 ]:
201.2ºC

[ 精确质量 ]:
210.088348

[ PSA ]:
125.22000

[ LogP ]:
1.35480

[ 外观性状 ]:
白色结晶粉末

[ 储存条件 ]:
库房通风低温干燥

L-精氨酸盐酸盐MSDS

L-精氨酸盐酸盐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CF1995500

CHEMICAL NAME :: Arginine, monohydrochloride, L-

CAS REGISTRY NUMBER :: 1119-34-2

LAST UPDATED :: 199701

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C6-H14-N4-O2.Cl-H

MOLECULAR WEIGHT :: 210.70

WISWESSER LINE NOTATION :: MUYZM3YZVQ &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 12 gm/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 62,49,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3793 mg/kg

TOXIC EFFECTS :: Behavioral - coma Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: ABBIA4 Archives of Biochemistry and Biophysics. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.31- 1951- Volume(issue)/page/year: 58,253,1955 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 90 mg/kg

SEX/DURATION :: female 1-6 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: AJEBAK Australian Journal of Experimental Biology and Medical Science. (Adelaide, S.A., Australia) V.1-64, 1924-86. Volume(issue)/page/year: 51,553,1973 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81859 No. of Facilities: 86 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 857 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81859 No. of Facilities: 585 (estimated) No. of Industries: 3 No. of Occupations: 13 No. of Employees: 5477 (estimated) No. of Female Employees: 2954 (estimated)

L-精氨酸盐酸盐安全信息

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S37/39-S26-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
CF1995500

[ 海关编码 ]:
2922499990

L-精氨酸盐酸盐合成路线

L-精氨酸盐酸盐上下游产品

L-精氨酸盐酸盐上游产品

L-精氨酸盐酸盐下游产品

L-精氨酸盐酸盐制备

明胶水解法、猪毛（或猪血粉等）水解法。由L-精氨酸与盐酸作用而成。

L-精氨酸盐酸盐海关

[ 海关编码 ]: 2922499990

[ 中文概述 ]:
2922499990 其他氨基酸及其酯及它们的盐（含有一种以上含氧基的除外）. 增值税率:17.0% 退税率:9.0% 监管条件:AB(入境货物通关单,出境货物通关单) 最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: P.进境动植物、动植物产品检疫 Q.出境动植物、动植物产品检疫 R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

L-精氨酸盐酸盐文献

Affinity precipitation of a monoclonal antibody from an industrial harvest feedstock using an ELP-Z stimuli responsive biopolymer.

Biotechnol. Bioeng. 111(8) , 1595-603, (2014)

In this work, a proof of concept elastin-like polypeptide-Z domain fusion (ELP-Z) based affinity precipitation process is developed for monoclonal antibody (mAb) purification from industrial harvest f...

Combinatorial effects of arginine and fluoride on oral bacteria.

J. Dent. Res. 94(2) , 344-53, (2015)

Dental caries is closely associated with the microbial disequilibrium between acidogenic/aciduric pathogens and alkali-generating commensal residents within the dental plaque. Fluoride is a widely use...

Evaluation of miR-216a and miR-217 as potential biomarkers of acute pancreatic injury in rats and mice.

Biomarkers 19(6) , 517-29, (2014)

Mild injury of the exocrine pancreas is often asymptomatic and can be under- or mis-diagnosed. The pancreas-enriched microRNAs miR-216a and miR-217 were evaluated as potential serum biomarkers of exoc...

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