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D-精氨酸

D-精氨酸用途

D-Arginine (H-D-Arg-OH) 是 Arginine 的 D 型异构体。Arginine 是一种用于合成蛋白质的 α-氨基酸。D-Arginine 是 L-Arginine 的非活性形式。

D-精氨酸名称

[ CAS 号 ]:
157-06-2

[ 中文名 ]:
D-精氨酸

[ 英文名 ]:
H-D-Arg-OH

[中文别名 ]:

[英文别名 ]:

(R)-2-Amino-5-guanidinopentanoic acid
EINECS 205-866-5
H-D-Arg-OH
D-ARGININE BASE
R-(-)-ARGININE
D-ornithine, N-(diaminomethylene)-
(2R)-2-amino-5-guanidinopentanoic acid
D-Arg-OH
D-ARG.FREE BASE
D-2-Amino-5-guanidinovalerate

D-精氨酸生物活性

[ 描述 ]:

D-Arginine (H-D-Arg-OH) 是 Arginine 的 D 型异构体。Arginine 是一种用于合成蛋白质的 α-氨基酸。D-Arginine 是 L-Arginine 的非活性形式。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Eduardo Navarro , et al. Toxicological and Pharmacological Effects of D-arginine. Basic Clin Pharmacol Toxicol. 2005 Sep;97(3):149-54.

D-精氨酸物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
367.6±52.0 °C at 760 mmHg

[ 熔点 ]:
221-224ºC

[ 分子式 ]:
C₆H₁₄N₄O₂

[ 分子量 ]:
174.201

[ 闪点 ]:
176.1±30.7 °C

[ 精确质量 ]:
174.111679

[ PSA ]:
125.22000

[ LogP ]:
-1.79

[ 外观性状 ]:
白色至淡黄色晶体粉末

[ 蒸汽压 ]:
0.0±1.8 mmHg at 25°C

[ 折射率 ]:
1.601

[ 储存条件 ]:
室温

D-精氨酸MSDS

D-精氨酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H319

[ 警示性声明 ]:
P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36

[ 安全声明 (欧洲) ]:
S26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
CF1934220

[ 海关编码 ]:
2925290090

D-精氨酸合成路线

D-精氨酸上下游产品

D-精氨酸上游产品

D-精氨酸下游产品

D-精氨酸制备

【方法一】
以D-鸟氨酸盐酸盐为原料，碳酸铜处理后与O-甲基异脲在碱性条件下反应得粗品，再用2，4-硝基-1-萘-7-磺酸沉淀，盐酸与水重结晶得产品。

D-精氨酸海关

[ 海关编码 ]: 2925290090

[ 中文概述 ]:
2925290090 其他亚胺及其衍生物，以及它们的盐。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

D-精氨酸文献

Cloning a neutral protease of Clostridium histolyticum, determining its substrate specificity, and designing a specific substrate.

Appl. Microbiol. Biotechnol. 99 , 10489-99, (2015)

Islet transplantation is a prospective treatment for restoring normoglycemia in patients with type 1 diabetes. Islet isolation from pancreases by decomposition with proteolytic enzymes is necessary fo...

Arginase promotes skeletal muscle arteriolar endothelial dysfunction in diabetic rats.

Front. Immunol. 4 , 119, (2013)

Endothelial dysfunction is a characteristic feature in diabetes that contributes to the development of vascular disease. Recently, arginase has been implicated in triggering endothelial dysfunction in...

Simultaneous determination of 18 D-amino acids in rat plasma by an ultrahigh-performance liquid chromatography-tandem mass spectrometry method: application to explore the potential relationship between Alzheimer's disease and D-amino acid level alterations.

Anal. Bioanal. Chem 408 , 141-50, (2016)

D-Amino acids are increasingly being recognized as important signaling molecules, and abnormal levels of D-amino acids have been implicated in the pathogenesis of Alzheimer's disease. To evaluate the ...

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