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4-DAMP

4-DAMP用途

4-DAMP是M3受体的一种有效拮抗剂,对密切相关的M5受体也有很高的亲和力[1]。

4-DAMP名称

[ CAS 号 ]:
1952-15-4

[ 中文名 ]:
4-二苯乙酰氧基-N-甲基-哌啶甲碘化物

[ 英文名 ]:
4-DAMP

[英文别名 ]:

4-diphenylacetoxy-1,1-dimethyl-piperidinium,iodide
4-Damp methiodide
4-DAMP methyliodide
4-diphenylacetoxy-N-methylpiperidinemethiodide
4-DAMP
diphenylacetoxy-N-methylpiperidine methiodide
MFCD00078564
4-Diphenylacetoxy-N-methylpiperidine methiodide
4-DAMP iodide
4-Diphenylacetoxy-1,1-dimethyl-piperidinium,Jodid

4-DAMP生物活性

[ 描述 ]:

4-DAMP是M3受体的一种有效拮抗剂,对密切相关的M5受体也有很高的亲和力[1]。

[ 相关类别 ]:

信号通路 >> 神经信号通路 >> mAChR

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 由mAChR

研究领域 >> 炎症/免疫

[参考文献]

[1]. Watson N, et al. Comparative pharmacology of recombinant human M3 and M5 muscarinic receptors expressed in CHO-K1 cells. Br J Pharmacol. 1999 May;127(2):590-6.

4-DAMP物理化学性质

[ 分子式 ]:
C₂₁H₂₆INO₂

[ 分子量 ]:
451.34

[ 精确质量 ]:
451.100800

[ PSA ]:
26.30000

[ LogP ]:
0.56330

[ 储存条件 ]:
-20°C，密闭，干燥

4-DAMPMSDS

4-DAMP安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2933399090

4-DAMP合成路线

4-DAMP上下游产品

4-DAMP上游产品

4-DAMP下游产品

4-DAMP海关

[ 海关编码 ]: 2933399090

[ 中文概述 ]:
2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

4-DAMP文献

A Distinct Class of Slow (∼0.2-2 Hz) Intrinsically Bursting Layer 5 Pyramidal Neurons Determines UP/DOWN State Dynamics in the Neocortex.

J. Neurosci. 35(14) , 5442-58, (2015)

During sleep and anesthesia, neocortical neurons exhibit rhythmic UP/DOWN membrane potential states. Although UP states are maintained by synaptic activity, the mechanisms that underlie the initiation...

Activation of muscarinic M3 receptors inhibits large-conductance voltage- and Ca2+-activated K+ channels in rat urinary bladder smooth muscle cells.

Am. J. Physiol. Cell Physiol. 305(2) , C207-14, (2013)

Large conductance voltage- and Ca(2+)-activated K(+) (BK) channels are key regulators of detrusor smooth muscle (DSM) contraction and relaxation during urine voiding and storage. Here, we explored whe...

Evidence for respiratory neuromodulator interdependence after cholinergic disruption in the ventral respiratory column.

Respir. Physiol. Neurobiol. 205 , 7-15, (2014)

Reverse dialysis of the muscarinic receptor antagonist, atropine (ATR, 50 mM), into the pre-Bötzinger Complex region of the ventral respiratory column (VRC) of awake and sleeping goats increases breat...

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