对氨基苯乙醚

对氨基苯乙醚用途

用作医药、染料、食品防腐剂、饲料添加剂、橡胶防老剂的中间体
该品用于生产橡胶防老剂AW，即6-乙氧基-2,2,4-三甲基-1,2-二氢化喹啉。也用于饲料和食品，可防止脂肪、蛋白质在贮存过程中氧化变质，还用于维生素A和维生素E等药品的保存。作为饲料和食品抗氧化剂时，称乙氧喹（[91-53-27]）。在医药方面，用于生产解热镇痛药非那西丁、安痨息和消毒防腐药利凡诺。在染料方面，该品是色酚AS-VL、茜素红5G和坚牢酸性蓝R的中间体。
测定铜、铁、锰、钒、锌、铬酸盐和氰化物。氧化还原指示剂。有机合成。染料制造

对氨基苯乙醚名称

[ CAS 号 ]:
156-43-4

[ 中文名 ]:
对乙氧基苯胺

[ 英文名 ]:
2-Phenoxyethanamine

[中文别名 ]:

[英文别名 ]:

2-Phenoxyethanamine
4-Aminophenetole
p-Phenetidine
MFCD00007865
EINECS 205-855-5
2-Phenoxy-ethylamine
Ethanamine, 2-phenoxy-
Phenetidine
4-Ethoxyaniline

对氨基苯乙醚物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
230.3±23.0 °C at 760 mmHg

[ 熔点 ]:
2-5 °C(lit.)

[ 分子式 ]:
C₈H₁₁NO

[ 分子量 ]:
137.179

[ 闪点 ]:
97.9±15.9 °C

[ 精确质量 ]:
137.084061

[ PSA ]:
35.25000

[ LogP ]:
0.89

[ 外观性状 ]:
无色液体

[ 蒸汽压 ]:
0.1±0.5 mmHg at 25°C

[ 折射率 ]:
1.527

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开储运

[ 稳定性 ]:
Stability Stable, but light and air sensitive. Combustible. Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
practically insoluble

对氨基苯乙醚MSDS

详细MSDS(安全技术说明书)

对氨基苯乙醚毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SI6465500

CHEMICAL NAME :: p-Phenetidine

CAS REGISTRY NUMBER :: 156-43-4

BEILSTEIN REFERENCE NO. :: 0606666

LAST UPDATED :: 199807

DATA ITEMS CITED :: 17

MOLECULAR FORMULA :: C8-H11-N-O

MOLECULAR WEIGHT :: 137.20

WISWESSER LINE NOTATION :: ZR DO2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Rinsed with water

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 540 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 487 mg/m3/4H

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - lacrimation Lungs, Thorax, or Respiration - respiratory depression Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 530 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 692 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 7 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2353 mg/kg

TOXIC EFFECTS :: Cardiac - other changes Lungs, Thorax, or Respiration - emphysema Kidney, Ureter, Bladder - hematuria

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1120 mg/kg/28D-I

TOXIC EFFECTS :: Endocrine - changes in spleen weight Blood - changes in bone marrow (not otherwise specified) Blood - changes in erythrocyte (RBC) count

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 15250 ug/kg/9W-I

TOXIC EFFECTS :: Blood - normocytic anemia Blood - methemoglobinemia-carboxyhemoglobin Blood - other changes

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 45750 ug/kg/9W-I

TOXIC EFFECTS :: Blood - normocytic anemia Blood - methemoglobinemia-carboxyhemoglobin Blood - other changes

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 160 umol/L

REFERENCE :: MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year: 3,51,1988 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4375 No. of Facilities: 6 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 206 (estimated) No. of Female Employees: 23 (estimated)

对氨基苯乙醚安全信息

[ 符号 ]:

GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H311-H319-H332-H334

[ 警示性声明 ]:
P261-P280-P305 + P351 + P338-P342 + P311

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
T:Toxic;Xn:Harmful;

[ 风险声明 (欧洲) ]:
R20/21/22;R23/24/25;R33;R36;R43;R68

[ 安全声明 (欧洲) ]:
S28-S36/37-S45-S46

[ 危险品运输编码 ]:
UN 2311 6.1/PG 3

[ WGK德国 ]:
1

[ RTECS号 ]:
SI6465500

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1

[ 海关编码 ]:
29222200

对氨基苯乙醚合成路线

详细合成路线

对氨基苯乙醚上下游产品

对氨基苯乙醚上游产品

对氨基苯乙醚下游产品

对氨基苯乙醚制备

1.由对硝基苯乙醚（[100-29-8]）还原而得。将硫化钠、硫磺加水升温至138-142℃，溶液静置澄清后加入还原锅内。加热搅拌，于5-6.5h内均匀缓慢加完对硝基苯乙醚，在132-134℃常压反应3h，在138-140℃加压（0.1MPa以下）反应10-12h。加水搅拌后静置1h。分去下层硫代硫酸钠母液，上层油层分净残渣，减压蒸馏，收集168-170℃（5.33kPa）馏分，得含量99%的对乙氧基苯胺。收率95%以上。也可采用加氢还原，以镍作催化剂，在130-140℃，0.6MPa压力下通氢反应，对硝基苯乙醚还原为对乙氧基苯胺。另外，以硝基苯为原料，在硫酸存在下，采用氧化镍为催化剂，二甲亚砜为促进剂，与无水乙醇乙氧基化，并还原一步制得对乙氧基苯胺。

2.对氨基苯酚法　经与氯乙烷反应制得。

对氨基苯乙醚海关

[ 海关编码 ]: 2922291000

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ Summary ]:
2922291000 4-methoxyaniline。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。Lowest tariff:6.5%。General tariff:30.0%

对氨基苯乙醚文献

Biotransformation and nitroglycerin-induced effects on antioxidative defense system in rat erythrocytes and reticulocytes.

Gen. Physiol. Biophys. 33(4) , 393-401, (2014)

The effects of nitroglycerin (glyceryl trinitrate - GTN) are mediated by liberated nitric oxide (NO) and formed reactive nitrogen species, which induces oxidative stress during biotransformation in re...

Magnetic beads as an extraction medium for simultaneous quantification of acetaminophen and structurally related compounds in human serum.

Drug Test. Anal. 7 , 457-66, (2015)

This paper describes a sample preparation method that complements a previously published liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay for acetaminophen and eight structurally-relate...

Metabolic activation by human arylacetamide deacetylase, CYP2E1, and CYP1A2 causes phenacetin-induced methemoglobinemia.

Biochem. Pharmacol. 84(9) , 1196-206, (2012)

Phenacetin has been used as an analgesic antipyretic but has now been withdrawn from the market due to adverse effects such as methemoglobinemia and renal failure. It has been suggested that metabolic...

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