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羟丁酰胺苯醚

羟丁酰胺苯醚用途

Bucetin (3-Hydroxy-p-butyrophenetidide)是一种解热镇痛化合物。

羟丁酰胺苯醚名称

[ CAS 号 ]:
1083-57-4

[ 中文名 ]:
羟丁酰胺苯醚

[ 英文名 ]:
Bucetin

[中文别名 ]:

[英文别名 ]:

N-(4-ethoxyphenyl)-3-hydroxybutanamide
N-(3-Hydroxybutyryl)-p-phenetidine
MFCD00021906
3-Hydroxy-p-butyrophenetidine
4'-Ethoxy-3-hydroxybutyranilide
Bucetin

羟丁酰胺苯醚生物活性

[ 描述 ]:

Bucetin (3-Hydroxy-p-butyrophenetidide)是一种解热镇痛化合物。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 其他

[相关活性小分子]

羟丁酰胺苯醚物理化学性质

[ 密度 ]:
1.151g/cm3

[ 沸点 ]:
433.5ºC at 760 mmHg

[ 熔点 ]:
160ºC

[ 分子式 ]:
C₁₂H₁₇NO₃

[ 分子量 ]:
223.26800

[ 闪点 ]:
216ºC

[ 精确质量 ]:
223.12100

[ PSA ]:
58.56000

[ LogP ]:
1.86770

[ 外观性状 ]:
固体;White to Almost white powder to crystal

[ 蒸汽压 ]:
2.77E-08mmHg at 25°C

[ 折射率 ]:
1.558

[ 储存条件 ]:
室温

羟丁酰胺苯醚MSDS

羟丁酰胺苯醚毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EU0900000

CHEMICAL NAME :: p-Butyrophenetidide, 3-hydroxy-

CAS REGISTRY NUMBER :: 1083-57-4

BEILSTEIN REFERENCE NO. :: 2725755

LAST UPDATED :: 199701

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C12-H17-N-O3

MOLECULAR WEIGHT :: 223.30

WISWESSER LINE NOTATION :: Q3VMR DO2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 7 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 790 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 958 gm/kg/76W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 479 gm/kg/76W-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 2 umol/plate

REFERENCE :: CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 33,2877,1985

羟丁酰胺苯醚安全信息

[ 符号 ]:

GHS07, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H312-H332-H350

[ 警示性声明 ]:
P201-P280-P308 + P313

[ 个人防护装备 ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T

[ 风险声明 (欧洲) ]:
45-46-20/21/22

[ 安全声明 (欧洲) ]:
53-22-36/37/39-45

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
EU0900000

[ 海关编码 ]:
2924299090

羟丁酰胺苯醚合成路线

羟丁酰胺苯醚上下游产品

羟丁酰胺苯醚上游产品

羟丁酰胺苯醚下游产品

羟丁酰胺苯醚海关

[ 海关编码 ]: 2924299090

[ 中文概述 ]:
2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

羟丁酰胺苯醚文献

Carcinogenicity of bucetin in (C57BL/6 X C3H)F1 mice.

J. Natl. Cancer Inst. 79(5) , 1151-8, (1987)

The carcinogenicity of bucetin [(3-hydroxy-p-butyrophenetidide) CAS: 1083-57-4], an antipyretic analgesic drug, was examined in 300 (C57BL/6 X C3H)F1 mice. Groups of 50 mice of each sex were treated w...

Mechanism of metabolic activation of the analgetic bucetin to bacterial mutagens by hamster liver microsomes.

Chem. Pharm. Bull. 33(7) , 2877-85, (1985)

[Biopharmaceutical studies of drugs. III. Serum concentration level of o-ethoxybenzamide and N-(beta-hydroxybutyryl)-p-phenetidine after simultaneous administration to rabbit (author's transl)].

Yakugaku Zasshi 101(6) , 556-66, (1981)

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