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安帕来斯

安帕来斯用途

Ampalex (Ampakine CX516; CX516; BDP 12)是AMPA受体阳性变构调节剂，可作用于阿尔茨海默病，精神分裂等。

安帕来斯名称

[ CAS 号 ]:
154235-83-3

[ 中文名 ]:
安帕来斯

[ 英文名 ]:
Ampalex

[中文别名 ]:

[英文别名 ]:

Methanone, 1-piperidinyl-6-quinoxalinyl-
piperidin-1-yl(quinoxalin-6-yl)methanone
1-Piperidinyl(6-quinoxalinyl)methanone
1-(quinoxalin-6-ylcarbonyl)piperidine
Ampalex
BDP-12

安帕来斯生物活性

[ 描述 ]:

Ampalex (Ampakine CX516; CX516; BDP 12)是AMPA受体阳性变构调节剂,可作用于阿尔茨海默病,精神分裂等。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> iGluR

信号通路 >> 神经信号通路 >> iGluR

研究领域 >> 神经疾病

[参考文献]

[1]. Broberg BV, Glenth?j BY, Dias R, et al. Reversal of cognitive deficits by an ampakine (CX516) and sertindole in two animal models of schizophrenia--sub-chronic and early postnatal PCP treatment in attentional set-shifting. Psychopharmacology (Berl). 2009

[2]. Kanju PM, Parameshwaran K, Sims C, et al. Ampakine CX516 ameliorates functional deficits in AMPA receptors in a hippocampal slice model of protein accumulation. Exp Neurol. 2008 Nov;214(1):55-61.

[3]. Goff DC, Lamberti JS, Leon AC, et al. A placebo-controlled add-on trial of the Ampakine, CX516, for cognitive deficits in schizophrenia. Neuropsychopharmacology. 2008 Feb;33(3):465-72.

[4]. O'Neill MJ, Witkin JM. AMPA receptor potentiators: application for depression and Parkinson's disease. Curr Drug Targets. 2007 May;8(5):603-20.

[5]. Johnson SA, Simmon VF. Randomized, double-blind, placebo-controlled international clinical trial of the Ampakine CX516 in elderly participants with mild cognitive impairment: a progress report. J Mol Neurosci. 2002 Aug-Oct;19(1-2):197-200.

[相关活性小分子]

安帕来斯物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
433.1±25.0 °C at 760 mmHg

[ 熔点 ]:
88-90ºC

[ 分子式 ]:
C₁₄H₁₅N₃O

[ 分子量 ]:
241.288

[ 闪点 ]:
215.8±23.2 °C

[ 精确质量 ]:
241.121506

[ PSA ]:
46.09000

[ LogP ]:
0.57

[ 外观性状 ]:
黄褐色固体

[ 蒸汽压 ]:
0.0±1.0 mmHg at 25°C

[ 折射率 ]:
1.640

[ 储存条件 ]:
2~8℃

安帕来斯安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
TM2785170

[ 海关编码 ]:
2933990090

安帕来斯海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%