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磺胺醋酰

磺胺醋酰用途

主要用于治疗结膜炎、砂眼及其他眼部感染等病症

磺胺醋酰名称

[ CAS 号 ]:
144-80-9

[ 中文名 ]:
磺胺醋酰

[ 英文名 ]:
sulfacetamide

[中文别名 ]:

[英文别名 ]:

A-500
Solfacetamide [DCIT]
Alesten
EINECS 205-640-6
Acetocid
Oclucid
Sulamyd
N-[(4-Aminophenyl)sulfonyl]acetamide
sulfacetamidum
ALBUCID SOLUBLE

磺胺醋酰生物活性

[ 描述 ]:

Sulfacetamide (Sulphacetamide) 是一种抑菌磺胺,是治疗眼部感染的常用抗生素。

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 细菌

[参考文献]

[1]. D Smit. Anti-infective ophthalmic preparations in general practice, South African Family Practice, 54:4, 302-307.

[2]. N. Rajesh Goud,et al. Modulating the solubility of sulfacetamide by means of cocrystals†

磺胺醋酰物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 熔点 ]:
182-184 °C

[ 分子式 ]:
C₈H₁₀N₂O₃S

[ 分子量 ]:
214.242

[ 精确质量 ]:
214.041214

[ PSA ]:
97.64000

[ LogP ]:
-0.96

[ 外观性状 ]:
白色至淡黄色结晶粉末

[ 蒸汽压 ]:
0.04mmHg at 25°C

[ 折射率 ]:
1.584

[ 储存条件 ]:
0-6°C

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents, strong bases, strong reducing agents, strong acids.

[ 水溶解性 ]:
<0.01 g/100 mL at 16 ºC

磺胺醋酰MSDS

磺胺醋酰毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AC8450000

CHEMICAL NAME :: Acetamide, N-sulfanilyl-

CAS REGISTRY NUMBER :: 144-80-9

BEILSTEIN REFERENCE NO. :: 0981718

LAST UPDATED :: 199701

DATA ITEMS CITED :: 14

MOLECULAR FORMULA :: C8-H10-N2-O3-S

MOLECULAR WEIGHT :: 214.26

WISWESSER LINE NOTATION :: ZR DSWMV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 16500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 606 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex)

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 8 gm/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - rigidity (including catalepsy)

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 5 gm/kg

TOXIC EFFECTS :: Behavioral - rigidity (including catalepsy) Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 10 gm/kg

SEX/DURATION :: female 10 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 1 gm/L

REFERENCE :: EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 10(Suppl 10),1,1987 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80537 No. of Facilities: 68 (estimated) No. of Industries: 1 No. of Occupations: 6 No. of Employees: 2770 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80537 No. of Facilities: 17 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 1639 (estimated) No. of Female Employees: 1344 (estimated)

磺胺醋酰安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R20/21/22

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
3249

[ WGK德国 ]:
2

[ RTECS号 ]:
AC8450000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
2935009090

磺胺醋酰合成路线

磺胺醋酰上下游产品

磺胺醋酰上游产品

磺胺醋酰下游产品

磺胺醋酰制备

磺胺醋酰钠酸化而得，将磺胺醋酸钠溶解于水中，用5%盐酸调节至pH3.8-4，析出磺胺醋酰。过滤，水洗，干燥得成品。

磺胺醋酰海关

[ 海关编码 ]: 2924299090

[ 中文概述 ]:
2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

磺胺醋酰文献

Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

J. Sci. Ind. Res. 65(10) , 808, (2006)

Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI typ...

Simultaneous determination of sulfonamides and metabolites in manure samples by one-step ultrasound/microwave-assisted solid-liquid-solid dispersive extraction and liquid chromatography-mass spectrometry.

Anal. Bioanal. Chem 407(13) , 3545-54, (2015)

An in-line matrix cleanup method was used for the simultaneous extraction of 15 sulfonamides and two metabolites from manure samples. The ultrasound/microwave-assisted extraction (UMAE) combined with ...

Concentration and distribution of antibiotics in water-sediment system of Bosten Lake, Xinjiang.

Environ. Sci. Pollut. Res. Int. 22(3) , 1670-8, (2015)

This study investigated the residues of four sulfonamides, four quinolones, and four tetracyclines in surface water as well as surficial sediment samples, of Bosten Lake, in Xinjiang, China. The resul...

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