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对乙酰氨基苯磺酰氯

对乙酰氨基苯磺酰氯用途

【用途一】
用于制备磺胺间二甲氧嘧啶、磺胺甲基异恶唑等磺胺类药
【用途二】
多种磺胺药物的中间体，如磺胺噻唑，磺胺异噁唑，磺胺甲基异噁唑，磺胺苯吡唑，磺胺二甲异嘧啶等。也是染料的中间体。

对乙酰氨基苯磺酰氯名称

[ CAS 号 ]:
121-60-8

[ 中文名 ]:
对乙酰胺基苯磺酰氯

[ 英文名 ]:
4-Acetamidobenzenesulfonyl chloride

[中文别名 ]:

[英文别名 ]:

4-Acetamidobenzenesulfonyl Chloride
Sulfanilyl chloride, N-acetyl-
P-ACETAMIDOBENZENE SULFONYL CHLORIDE ASC
4-ACETAMIDOBENZENESULFONYLCHLORIDE
P-ACETYLSULPHANILYL CHLORIDE
ASC
UNII-LIX4M9AIVM
p-Acetamidophenylsulfonyl chloride
4-ACETAMINOBENZENESULFONYL CHLORIDE
N-Acetylsulfanilylchloride

对乙酰氨基苯磺酰氯物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
426.8±28.0 °C at 760 mmHg

[ 熔点 ]:
142-145 °C (dec.)(lit.)

[ 分子式 ]:
C₈H₈ClNO₃S

[ 分子量 ]:
233.672

[ 闪点 ]:
211.9±24.0 °C

[ 精确质量 ]:
232.991348

[ PSA ]:
71.62000

[ LogP ]:
1.55

[ 外观性状 ]:
灰白色至略灰色粒状的结晶粉末

[ 蒸汽压 ]:
0.0±1.0 mmHg at 25°C

[ 折射率 ]:
1.586

[ 储存条件 ]:
库房通风低温干燥

[ 水溶解性 ]:
SLIGHTLY SOLUBLE

对乙酰氨基苯磺酰氯MSDS

对乙酰氨基苯磺酰氯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DB8837500

CHEMICAL NAME :: Benzenesulfonyl chloride, 4-(acetylamino)-

CAS REGISTRY NUMBER :: 121-60-8

LAST UPDATED :: 199710

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C8-H8-Cl-N-O3-S

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >3200 mg/kg

TOXIC EFFECTS :: Behavioral - muscle weakness Behavioral - ataxia

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0533583

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - muscle weakness Behavioral - ataxia

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0533583

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1600 mg/kg

TOXIC EFFECTS :: Behavioral - muscle weakness Behavioral - ataxia

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0533583

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Behavioral - muscle weakness Behavioral - ataxia

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0533583

对乙酰氨基苯磺酰氯安全信息

[ 符号 ]:

GHS05, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H314-H335

[ 警示性声明 ]:
P261-P280-P305 + P351 + P338-P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
C:Corrosive

[ 风险声明 (欧洲) ]:
R34

[ 安全声明 (欧洲) ]:
S26-S36/37/39-S45-S28B

[ 危险品运输编码 ]:
UN 3261 8/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
DB8837500

[ 包装等级 ]:
II

[ 危险类别 ]:
8

[ 海关编码 ]:
29242995

对乙酰氨基苯磺酰氯合成路线

对乙酰氨基苯磺酰氯上下游产品

对乙酰氨基苯磺酰氯上游产品

对乙酰氨基苯磺酰氯下游产品

对乙酰氨基苯磺酰氯制备

乙酰苯胺氯磺化下面是两个工业操作示例。操作示例1 搅拌下将67.5kg乙酰胺基苯加到290kg氯磺酸中，控制加料温度在15℃以下,加毕渐升温至60℃，保温搅拌2h，然后将反应物逐渐加于冰水中稀释，温度保持10℃以下，过滤，用冰水漂洗至刚果红试纸呈中性。得对乙酰氨基苯磺酰氯。操作示例2 在20℃ 以下将乙酰胺基苯均匀加入氯磺酸中，按重量计,乙酰苯胺：氯磺酸＝1:5.26，在50± 2℃反应3h。放置8h后，约20℃以下，加适量水分解过剩的氯磺酸，温度不超过28℃，稍冷，过滤，洗涤滤饼至pH=3-4，得对乙酰氨基磺酰氯。收率为83%。该品不宜久存，作为医药和染料生产的中间产物，含量为30%。

对乙酰氨基苯磺酰氯海关

[ 海关编码 ]: 2924299090

[ 中文概述 ]:
2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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J. Chromatogr. A. 949(1-2) , 11-22, (2002)

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J. Environ. Sci. Health B 48(1) , 9-15, (2013)

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