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4 -氨基苯甲酰基甘氨酸D-亮氨酸D-丙氨酸异羟肟酸

用途

FN-439是一种选择性胶原酶-1抑制剂。FN-439抑制胶原酶-1,IC50值为1μM。FN-439可用于癌症和炎症的研究[1][2]。

名称

[ CAS 号 ]:
124168-73-6

[ 中文名 ]:
4 -氨基苯甲酰基甘氨酸D-亮氨酸D-丙氨酸异羟肟酸

[ 英文名 ]:
4-Abz-Gly-Pro-D-Leu-D-Ala-NHOH trifluoroacetate salt

[中文别名 ]:

[英文别名 ]:

MFCD00237459

生物活性

[ 描述 ]:

FN-439是一种选择性胶原酶-1抑制剂。FN-439抑制胶原酶-1,IC50值为1μM。FN-439可用于癌症和炎症的研究[1][2]。

[ 相关类别 ]:

研究领域 >> 癌症

研究领域 >> 炎症/免疫

信号通路 >> 代谢酶/蛋白酶 >> MMP

[体外研究]

FN-439抑制胶原酶-1,IC50值为1μM[1]。FN-439(1μM)可降低MDA-MB-231乳腺癌细胞的侵袭潜能[1]。

[体内研究]

FN-439可显著减少中性粒细胞和巨噬细胞,与氧氟沙星联合使用时,在根尖周围区域表现出广泛的骨形成和活跃的骨水泥形成[2]。

物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 分子式 ]:
C₂₃H₃₄N₆O₆

[ 分子量 ]:
490.553

[ 精确质量 ]:
490.253998

[ PSA ]:
182.96000

[ LogP ]:
-0.69

[ 外观性状 ]:
白色粉末

[ 折射率 ]:
1.583

MSDS

详细MSDS(安全技术说明书)

安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

文献

Impaired Focal Adhesion Kinase-Grb2 Interaction during Elevated Activity in Hippocampal Neurons.

Int. J. Mol. Sci. 16 , 15659-69, (2015)

Excitatory/inhibitory imbalances are implicated in many neurological disorders. Previously, we showed that chronically elevated network activity induces vulnerability in neurons due to loss of signal ...

Inhibition of matrix metalloproteinases by peptidyl hydroxamic acids.

Biochem. Biophys. Res. Commun. 199 , 1442-6, (1994)

Synthetic inhibitors of interstitial collagenase, tri- and tetrapeptidyl hydroxamic acids, have been developed and tested for their inhibitory activities against human matrix metalloproteinases. A wat...

Vertebrate collagenase inhibitor. II. Tetrapeptidyl hydroxamic acids.

Chem. Pharm. Bull. Tokyo 39 , 1489-1494, (1991)

To develop a potent and specific collagenase inhibitor, a series of tetrapeptidyl hydroxamic acids were synthesized, based on the previous findings with tripeptidyl derivatives (Chem. Pharm. Bull., 38...

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