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胆碱

胆碱用途

胆碱氢氧化物是一种胆碱氢氧化衍生物和一种强有机碱,可用作调节介质pH值的标准碱。胆碱是一种口服活性营养素,是卵磷脂和鞘磷脂的重要组成部分,促进脂肪代谢[1][2][3]。

胆碱名称

[ CAS 号 ]:
123-41-1

[ 中文名 ]:
(2-羟乙基)三甲基氢氧化铵

[ 英文名 ]:
Choline Hydroxide

[中文别名 ]:

[英文别名 ]:

Bursine
Gossypine
Sincaline
VIDINE
MFCD00002831
EINECS 204-625-1
2-Hydroxy-N,N,N-trimethylethanaminium hydroxide
Luridine
Fagine
Choline hydroxide

胆碱生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[体外研究]

氢氧化胆碱可用作标准碱,在蔗糖介质(pH值为7.08)中(0.5 M),pHo迅速转变为7.59[1]。氢氧化胆碱(0.1-0.5 g/mL)与有机羧酸一起制备离子液体,用于制备离子液反胶束载药系统,并参与表皮脱敏研究[2]。

[参考文献]

[1]. Mitchell P, et al. Estimation of membrane potential and pH difference across the cristae membrane of rat liver mitochondria. Eur J Biochem. 1969 Feb;7(4):471-84.

[2]. Ding Y, et al. An ionic liquid-reverse micelle drug delivery system for epidermal desensitization therapy and its preparation method and application: China, CN113975224. 2022-01-28.

[3]. Wang F, et al. Short communication: Effects of dietary deoiled soy lecithin supplementation on circulating choline and choline metabolites, and the plasma phospholipid profile in Holstein cows fed palm fat. J Dairy Sci. 2021 Feb;104(2):1838-1845.

胆碱物理化学性质

[ 密度 ]:
1.09 g/mL at 20 °C

[ 分子式 ]:
C₅H₁₅NO₂

[ 分子量 ]:
121.178

[ 闪点 ]:
92 °F

[ 精确质量 ]:
121.110275

[ PSA ]:
43.29000

[ 外观性状 ]:
透明淡黄色粘性溶液

[ 折射率 ]:
n20/D 1.4304

[ 储存条件 ]:
2-8°C

[ 稳定性 ]:
Stable. Combustible. Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
miscible

胆碱MSDS

详细MSDS(安全技术说明书)

胆碱毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GA4025500

CHEMICAL NAME :: Choline hydroxide

CAS REGISTRY NUMBER :: 123-41-1

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C5-H14-N-O.H-O

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 21400 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 23,1357,1968 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1710 No. of Facilities: 31 (estimated) No. of Industries: 1 No. of Occupations: 16 No. of Employees: 11518 (estimated) No. of Female Employees: 5852 (estimated)

胆碱安全信息

[ 危害码 (欧洲) ]:
C:Corrosive;

[ 风险声明 (欧洲) ]:
R35

[ 安全声明 (欧洲) ]:
S26-S36/37/39-S45

[ 危险品运输编码 ]:
UN 3286 3/PG 2

[ WGK德国 ]:
1

[ RTECS号 ]:
GA4025500

[ 包装等级 ]:
II

[ 危险类别 ]:
8

[ 海关编码 ]:
2923900090

胆碱合成路线

详细合成路线

胆碱上下游产品

胆碱上游产品

胆碱下游产品

胆碱制备

二、制备方法：由甲醛经氯化铵甲基化得到三甲胺后，再与环氧乙烷加成而得胆碱。

胆碱海关

[ 海关编码 ]: 2923900090

[ 中文概述 ]:
2923900090 其他季铵盐及季铵碱。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2923900090 other quaternary ammonium salts and hydroxides。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

胆碱