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胆碱

胆碱用途

有机合成中间体；用于生化研究。

胆碱名称

[ CAS 号 ]:
62-49-7

[ 中文名 ]:
L-胆碱

[ 英文名 ]:
choline

[中文别名 ]:

2-羟基-N,N,N-三甲基乙铵

[英文别名 ]:

2-hydroxy-N,N,N-trimethyl-Ethanaminium
CholineBitartrateFcc
(2-Hydroxyethyl)trimethyl ammonium
[3H]-Choline
(2-hydroxyethyl)trimethylammonium
(β-hydroxyethyl)trimethylammonium
choline
ChlolineBitartarate
cholinecation
(b-Hydroxyethyl)trimethylammonium

胆碱物理化学性质

[ 密度 ]:
1.09 g/mL at 20 °C

[ 分子式 ]:
C₅H₁₄NO

[ 分子量 ]:
104.170

[ 精确质量 ]:
104.106987

[ PSA ]:
20.23000

[ LogP ]:
-3.70

[ 折射率 ]:
n20/D 1.418

[ 储存条件 ]:
2-8°C

胆碱MSDS

详细MSDS(安全技术说明书)

胆碱毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: FZ9625000

CHEMICAL NAME :: Choline

CAS REGISTRY NUMBER :: 62-49-7

BEILSTEIN REFERENCE NO. :: 1736748

LAST UPDATED :: 199709

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C5-H14-N-O

MOLECULAR WEIGHT :: 104.20

WISWESSER LINE NOTATION :: Q2K1&1&1 &Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 35 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85IXA4 "Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948 Volume(issue)/page/year: -,358,1948

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85IXA4 "Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948 Volume(issue)/page/year: -,358,1948

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 70 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849- Volume(issue)/page/year: 83,481,1920

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Rectal

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 460 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849- Volume(issue)/page/year: 83,481,1920

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 450 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 85,642,1954

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Amphibian - frog

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84325 No. of Facilities: 707 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 2552 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84325 No. of Facilities: 139 (estimated) No. of Industries: 4 No. of Occupations: 7 No. of Employees: 4037 (estimated) No. of Female Employees: 19 (estimated)

胆碱安全信息

[ 危害码 (欧洲) ]:
C: Corrosive;

[ 风险声明 (欧洲) ]:
34

[ 安全声明 (欧洲) ]:
S26-S36/37/39-S45

[ 危险品运输编码 ]:
UN 3286 3/PG 2

[ WGK德国 ]:
1

[ 包装等级 ]:
II

[ 危险类别 ]:
8

胆碱合成路线

详细合成路线

胆碱上下游产品

胆碱上游产品

胆碱下游产品

胆碱制备

由甲醛经氯化铵甲基化得到三甲胺后，再与环氧乙烷加成而得胆碱。

胆碱