2-(二甲基氨基)乙醇

2-(二甲基氨基)乙醇用途

【用途一】
用作医药原料，制造染料、纤维处理剂、防腐添加剂等的中间体，可作水溶性涂料基料、合成树脂溶剂等
【用途二】
用作染料中间体、织物的助染剂及防腐剂，也用于制药工业
【用途三】
该品用于离子交换树脂、聚氨酯催化剂、医药（局部麻醉剂盐酸丁卡因、抗组胺剂，镇痉剂和抗高血压药物等）、乳化剂、纺织助剂、阻蚀剂、防垢剂、染料及油漆溶剂、合成763树脂及其固化剂等；还用于燃料油添加剂，作为丙烯酸衍生物而用作城市净水场的絮凝剂。在日本，该品的50%用于离子交换树脂，13.8%用于聚氨酯催化剂，涂料方面的消费占11.2%。
【用途四】
二甲基乙醇胺DMEA（108-01-0）可用于制备可用水稀释涂料,也是甲基丙烯酸二甲氨乙基酯的原料,丙烯酸酯用于制备抗静电剂、土壤调节剂、导电材料、纸张助剂和絮凝胶；二甲基乙醇胺DMEA还用于水处理剂，防止锅炉腐蚀。
在聚氨酯泡沫塑料中，二甲基乙醇胺DMEA（108-01-0）是一种辅助催化剂，也是一种反应性催化剂，二甲基乙醇胺DMEA可用于聚氨酯软泡和聚氨酯硬泡配方。在二甲基乙醇胺DMEA的分子中有一羟基，能与异氰酸酯基反应，因此二甲基乙醇胺DMEA（108-01-0）可以结合在聚合物分子上，不致像三乙胺那样易挥发。
【用途五】
用于抗抑制剂、染料中间体、织物的助染剂、制药工业防腐剂、用作树脂原料。

2-(二甲基氨基)乙醇名称

[ CAS 号 ]:
108-01-0

[ 中文名 ]:
N,N-二甲基乙醇胺

[ 英文名 ]:
2-(Dimethylamino)ethanol

[中文别名 ]:

[英文别名 ]:

2-hydroxy-N,N-dimethyl-benzamide
N,N-dimethyl-salicylamide
2-Dimethylaminoethanol
N,N-Dimethyl-salicylamid
salicylic acid dimethylamide
MFCD00002846
N,N-dimethyl-2-hydroxybenzamide
EINECS 203-542-8
2-(dimethylamino)-1-ethanol
Salicylamide,N,N-dimethyl

2-(二甲基氨基)乙醇物理化学性质

[ 密度 ]:
0.9±0.1 g/cm3

[ 沸点 ]:
135.0±0.0 °C at 760 mmHg

[ 熔点 ]:
−70 °C(lit.)

[ 分子式 ]:
C₄H₁₁NO

[ 分子量 ]:
89.136

[ 闪点 ]:
40.6±0.0 °C

[ 精确质量 ]:
89.084061

[ PSA ]:
23.47000

[ LogP ]:
-0.33

[ 外观性状 ]:
透明至淡黄色液体

[ 蒸汽压 ]:
3.4±0.5 mmHg at 25°C

[ 折射率 ]:
1.433

[ 储存条件 ]:
库房通风低温干燥,与氧化剂、酸类分开存放

[ 稳定性 ]:
Stable. Flammable. Incompatible with oxidizing agents, copper, copper alloys, zinc, acids, galvanised iron. Hygroscopic.

[ 水溶解性 ]:
miscible

[ 凝固点 ]:
-59.0℃

2-(二甲基氨基)乙醇MSDS

详细MSDS(安全技术说明书)

2-(二甲基氨基)乙醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KK6125000

CHEMICAL NAME :: Ethanol, 2-dimethylamino-

CAS REGISTRY NUMBER :: 108-01-0

BEILSTEIN REFERENCE NO. :: 1209235

LAST UPDATED :: 199806

DATA ITEMS CITED :: 17

MOLECULAR FORMULA :: C4-H11-N-O

MOLECULAR WEIGHT :: 89.16

WISWESSER LINE NOTATION :: Q2N1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 12/15/1971 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ZHYGAM Zeitschrift fuer die Gesamte Hygiene und Ihre Grenzgebiete. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1955- Volume(issue)/page/year: 20,393,1974

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1641 ppm/4H

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - lacrimation Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 9,512,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1080 mg/kg

TOXIC EFFECTS :: Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 12,486,1968

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3250 mg/m3

TOXIC EFFECTS :: Brain and Coverings - recordings from specific areas of CNS Sense Organs and Special Senses (Eye) - conjunctive irritation Behavioral - convulsions or effect on seizure threshold

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 14(11),52,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 234 mg/kg

TOXIC EFFECTS :: Behavioral - ataxia

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 94,249,1948

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 961 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - coma Lungs, Thorax, or Respiration - other changes

REFERENCE :: AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 225,428,1955

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1370 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU. Volume(issue)/page/year: 4,119,1951

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 450 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 85,642,1954 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 670 mg/m3/4H/22W-I

TOXIC EFFECTS :: Endocrine - changes in adrenal weight Blood - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 14(11),52,1970

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 288 ppm/6H/2W-I

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - corneal damage Behavioral - food intake (animal) Related to Chronic Data - death

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 9,512,1987

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 76 ppm/6H/13W-I

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 9,512,1987 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 5 mg/m3;Skin JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83678 No. of Facilities: 249 (estimated) No. of Industries: 9 No. of Occupations: 23 No. of Employees: 6372 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83678 No. of Facilities: 1838 (estimated) No. of Industries: 44 No. of Occupations: 36 No. of Employees: 33474 (estimated) No. of Female Employees: 5559 (estimated)

2-(二甲基氨基)乙醇安全信息

[ 符号 ]:

GHS02, GHS05, GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H226-H302 + H312-H314-H331

[ 警示性声明 ]:
P261-P280-P305 + P351 + P338-P310

[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
C:Corrosive

[ 风险声明 (欧洲) ]:
R10;R20/21/22;R34

[ 安全声明 (欧洲) ]:
S25-S26-S36/37/39-S45

[ 危险品运输编码 ]:
UN 2051 8/PG 2

[ WGK德国 ]:
1

[ RTECS号 ]:
KK6125000

[ 包装等级 ]:
II

[ 危险类别 ]:
8

[ 海关编码 ]:
2922192210

2-(二甲基氨基)乙醇合成路线

详细合成路线

2-(二甲基氨基)乙醇上下游产品

2-(二甲基氨基)乙醇上游产品

2-(二甲基氨基)乙醇下游产品

2-(二甲基氨基)乙醇制备

1.环氧乙烷法由二甲胺与环氧乙烷进行氨化，经蒸馏、精馏、脱水而得。

2.氯乙醇法由氯乙醇与碱进行皂化生成环氧乙烷，再与二甲胺合成得到二甲氨基乙醇。工业品二甲氨基乙醇，纯度≥95%。原料消耗定额：氯乙醇（32%）5500kg/t、二甲胺（40%）2200kg/t。生产时，也可以将氯乙醇直接滴加到二甲胺中，收率为85%。

精制方法：常压或减压蒸馏精制。

2-(二甲基氨基)乙醇海关

[ 海关编码 ]: 2922192210

[ 中文概述 ]:
2922192210 2－二乙氨基乙醇〔或称N,N－二乙基乙醇胺〕。监管条件:3(两用物项和技术出口许可证)。增值税率:17.0%。退税率:9.0%。最低关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ 监管条件 ]: 3.两用物项和技术出口许可证

[ Summary ]:
2922192210 2-(diethylamino)ethanol。supervision conditions:3(export license for dual-use item and technologies)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:30.0%

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