二甲胺

二甲胺用途

1、用作生产药物、染料、农药、皮革去毛剂、橡胶硫化促进剂、火箭推进剂等的原料
2、二甲胺是农药的重要中间体，可以制备杀菌剂福美双、福美甲胂、福美锌、福美镍、福美砷、退菌特、二甲嘧酚，杀虫剂抗蚜威、杀虫双、杀虫单、杀螟丹、螟铃畏，除草剂绿麦隆、异丙隆、环嗪酮、氟草隆等。
3、主要用作橡胶硫化促进剂、皮革去毛剂、医药（抗菌素）、农药（福美双、杀虫脒、灭草隆等除草剂）、纺织工业溶剂、染料、炸药、推进剂及二甲肼、N，N-二甲基甲酰胺等有机中间体的原料。其中二甲基甲酰胺生产消耗的二甲胺占总消耗量的44.7%，农药生产消耗占38.9%，医药等生产消耗占16.4%。
4、用作基本有机化工原料、溶剂及助剂
5、用作分析试剂、酸性气体吸收剂、溶剂及有机合成中间体

二甲胺名称

[ CAS 号 ]:
124-40-3

[ 中文名 ]:
二甲胺

[ 英文名 ]:
Dimethylamine

[中文别名 ]:

[英文别名 ]:

N,N-dimethylamine
N-Methylmethanamine
Dimethylamine
N-methyl-Methanamine
MFCD00008288
Methanamine, N-methyl-
Me2NH
EINECS 204-697-4
Dacarbazine Impurity 4

二甲胺物理化学性质

[ 密度 ]:
0.6±0.1 g/cm3

[ 沸点 ]:
6.1±3.0 °C at 760 mmHg

[ 熔点 ]:
−93 °C(lit.)

[ 分子式 ]:
C₂H₇N

[ 分子量 ]:
45.084

[ 闪点 ]:
-56.1±8.8 °C

[ 精确质量 ]:
45.057850

[ PSA ]:
12.03000

[ LogP ]:
-0.43

[ 外观性状 ]:
无色压缩液化气体

[ 蒸汽密度 ]:
1.55 (vs air)

[ 蒸汽压 ]:
1520.3±0.0 mmHg at 25°C

[ 折射率 ]:
1.344

[ 储存条件 ]:
库房通风低温干燥,与氧化剂、酸类分开存放

[ 稳定性 ]:
Stable. Generally used as a solution in water at concentrations up to around 40%. Extremely flammable in the pure form. Incompatible with strong oxidizing agents.

二甲胺MSDS

详细MSDS(安全技术说明书)

二甲胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: IP8750000

CHEMICAL NAME :: Dimethylamine

CAS REGISTRY NUMBER :: 124-40-3

LAST UPDATED :: 199712

DATA ITEMS CITED :: 56

MOLECULAR FORMULA :: C2-H7-N

MOLECULAR WEIGHT :: 45.10

WISWESSER LINE NOTATION :: 1M1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 698 mg/kg

TOXIC EFFECTS :: Behavioral - excitement Behavioral - muscle weakness Gastrointestinal - ulceration or bleeding from stomach

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4540 ppm/6H

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Sense Organs and Special Senses (Eye) - effect, not otherwise specified Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 316 mg/kg

TOXIC EFFECTS :: Behavioral - excitement Behavioral - muscle weakness Gastrointestinal - ulceration or bleeding from stomach

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4725 ppm/2H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 736 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 240 mg/kg

TOXIC EFFECTS :: Behavioral - excitement Behavioral - muscle weakness Gastrointestinal - ulceration or bleeding from stomach

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 240 mg/kg

TOXIC EFFECTS :: Behavioral - excitement Behavioral - muscle weakness Gastrointestinal - ulceration or bleeding from stomach

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 3700 mg/m3

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 85 mg/kg/35W-I

TOXIC EFFECTS :: Behavioral - alteration of classical conditioning Liver - changes in liver weight Immunological Including Allergic - decrease in cellular immune response

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 37128 gm/kg/39W-C

TOXIC EFFECTS :: Liver - changes in liver weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 175 ppm/6H/1Y-I

TOXIC EFFECTS :: Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 175 ppm/6H/9D-I

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 175 ppm/6H/2Y-I

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 175 ppm/6H/1Y-I

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 175 ppm/6H/2Y-I

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 850 mg/kg/35W-I

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - other changes in urine composition Endocrine - other changes

TYPE OF TEST :: Cytogenetic analysis

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

REFERENCE :: MOTOEX Molecular Toxicology. (Taylor & Francis, Inc., 242 Cherry St., Philadelphia, PA USA 19106) V.1- 1987- Volume(issue)/page/year: 1,217,1987 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-STEL 27.6 mg/m3 (15 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 9.2 mg/m3 (5 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW CHREAY Chemical Reviews. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1924- Volume(issue)/page/year: 9,389,1931 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 10 ppm (18 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,88,1971 OSHA PEL (Gen Indu):8H TWA 10 ppm (18 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 10 ppm (18 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 10 ppm (18 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 10 ppm (18 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 10 ppm (18 mg/m3) JAN 1993 OEL-BELGIUM:TWA 10 ppm (18 mg/m3) JAN 1993 OEL-DENMARK:TWA 10 ppm (18 mg/m3) JAN 1993 OEL-FINLAND:STEL 10 ppm (18 mg/m3);Skin JAN 1993 OEL-FRANCE:STEL 10 ppm (18 mg/m3) JAN 1993 OEL-GERMANY:TWA 10 ppm (18 mg/m3) JAN 1993 OEL-HUNGARY:TWA 1 mg/m3;STEL 2 mg/m3;Skin JAN 1993 OEL-JAPAN:TWA 10 ppm (18 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 10 ppm (18 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 10 ppm (18 mg/m3) JAN 1993 OEL-RUSSIA:TWA 10 ppm;STEL 1 mg/m3;Skin JAN 1993 OEL-SWITZERLAND:TWA 10 ppm (18 mg/m3);STEL 20 ppm (36 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 10 ppm (18 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO DIMETHYLAMINE-air:10H TWA 10 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 26130 No. of Facilities: 291 (estimated) No. of Industries: 13 No. of Occupations: 16 No. of Employees: 3174 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1555 No. of Facilities: 32 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 65 (estimated) No. of Female Employees: 65 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 26130 No. of Facilities: 1406 (estimated) No. of Industries: 22 No. of Occupations: 42 No. of Employees: 28879 (estimated) No. of Female Employees: 2001 (estimated)

二甲胺安全信息

[ 符号 ]:

GHS02, GHS05, GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H301-H311-H315-H318-H331-H370

[ 警示性声明 ]:
P210-P260-P280-P301 + P310-P305 + P351 + P338-P311

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
F:Flammable

[ 风险声明 (欧洲) ]:
R12;R20;R37/38;R41

[ 安全声明 (欧洲) ]:
S3-S16-S26-S29-S36/37/39-S45-S39

[ 危险品运输编码 ]:
UN 2924 3/PG 2

[ WGK德国 ]:
2

[ RTECS号 ]:
IP8750000

[ 包装等级 ]:
II

[ 危险类别 ]:
3

[ 海关编码 ]:
2921110010

二甲胺合成路线

详细合成路线

二甲胺上下游产品

二甲胺上游产品

二甲胺下游产品

二甲胺制备

1.将甲醇和氨以一定比例混合，在一定温度和压力下，以活性氧化铝为催化剂，合成得一、二、三甲胺混合物，然后经热交换、冷凝、脱氨、萃取、脱水、分离，得二甲胺成品。

精制方法：常含有甲胺、三甲胺、氨和甲醇等杂质。可用加压蒸馏法精制。或者将二甲胺盐酸盐用乙醇反复重结晶，直至其熔点达到171℃。用氢氧化钾游离出二甲胺，再用干冰-乙醚冷却液体，固体氢氧化钾和芴酮钠干燥，可得纯净的二甲胺。其他的精制法有将二甲胺与对甲苯磺酸反应，转变成对甲苯磺酰胺。用70%乙醇重结晶，熔点达80~80.5℃后用盐酸水解使生成二甲胺盐酸盐，再按上述方法处理。

2.有弱碱性，与无机酸生成易溶于水的盐类。

二甲胺海关

[ 海关编码 ]: 2921110010

[ 中文概述 ]:
2921110010 二甲胺。监管条件:23(两用物项和技术进口许可证,两用物项和技术出口许可证)。增值税率:17.0%。退税率:9.0%。最低关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: 2.两用物项和技术进口许可证 3.两用物项和技术出口许可证

[ Summary ]:
2921110010 dimethylamine。supervision conditions:23(import license for dual-use item and technologies,export license for dual-use item and technologies)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:30.0%

二甲胺文献

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Dysregulated adipose tissue metabolism has been implicated in the pathogenesis of alcoholic liver disease in murine models. We aimed to characterize serum markers of adipose tissue metabolism and infl...

Hygroscopic and phase transition properties of alkyl aminium sulfates at low relative humidities.

Phys. Chem. Chem. Phys. 17 , 19789-96, (2015)

Alkyl aminium sulfates (AASs) can affect the physicochemical properties of atmospheric aerosols such as hygroscopicity. Previous laboratory experiments have shown that the water content in AAS bulk so...

Molecular understanding of sulphuric acid-amine particle nucleation in the atmosphere.

Nature 502(7471) , 359-63, (2013)

Nucleation of aerosol particles from trace atmospheric vapours is thought to provide up to half of global cloud condensation nuclei. Aerosols can cause a net cooling of climate by scattering sunlight ...

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二甲胺