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N-亚硝基二甲胺

N-亚硝基二甲胺用途

Dimethylnitrosamine (NDMA) 是一种强效的肝毒素、致癌剂和诱变剂。Dimethylnitrosamine 可用于诱发肝脏肿瘤。

N-亚硝基二甲胺名称

[ CAS 号 ]:
62-75-9

[ 中文名 ]:
N-亚硝基二甲胺

[ 英文名 ]:
N-Nitrosodimethylamine

[中文别名 ]:

[英文别名 ]:

N-NITROSODIMETHYLAMINE
dimethyl-nitrosoamine
EINECS 200-549-8
N-Methyl-N-nitrosomethanamine
MFCD00002053
Methanamine,N-methyl-N-nitroso
Dimethylnitrosamine
Nitrosodimethylamine
DMNA
[14C]-Dimethylnitrosamine

N-亚硝基二甲胺生物活性

[ 描述 ]:

Dimethylnitrosamine (NDMA) 是一种强效的肝毒素、致癌剂和诱变剂。Dimethylnitrosamine 可用于诱发肝脏肿瘤。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Haggerty HG, et, al. Role of metabolism in dimethylnitrosamine-induced immunosuppression: a review. Toxicology. 1990 Jul;63(1):1-23.

[2]. Takayama S, et, al. Sequential effects of chemically different carcinogens, dimethylnitrosamine and 4-dimethylaminoazobenzene, on hepatocarcinogenesis in rats. Int J Cancer. 1969 Jul 15;4(4):373-83.

N-亚硝基二甲胺物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
152.0±0.0 °C at 760 mmHg

[ 熔点 ]:
50ºC

[ 分子式 ]:
C₂H₆N₂O

[ 分子量 ]:
74.082

[ 闪点 ]:
36.1±18.7 °C

[ 精确质量 ]:
74.048012

[ PSA ]:
32.67000

[ LogP ]:
-0.64

[ 外观性状 ]:
黄色油性液体

[ 蒸汽压 ]:
4.6±0.2 mmHg at 25°C

[ 折射率 ]:
1.427

[ 储存条件 ]:
库房通风低温干燥,与氧化剂、食品添加剂分开存放

[ 稳定性 ]:
Stability Stable, but light-sensitive. Combustible. Incompatible with strong oxidizing agents, strong bases, strong reducing agents.

N-亚硝基二甲胺MSDS

N-亚硝基二甲胺安全信息

[ 符号 ]:

GHS02, GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H301 + H311 + H331-H350-H370

[ 警示性声明 ]:
P201-P210-P260-P280-P301 + P310-P311

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
T+,N,T,F

[ 风险声明 (欧洲) ]:
45-25-26-48/25-51/53-39/23/24/25-23/24/25-11

[ 安全声明 (欧洲) ]:
S53-S45-S61-S36/37

[ 危险品运输编码 ]:
UN 3382 6.1/PG 1

[ WGK德国 ]:
3

[ RTECS号 ]:
IQ0525000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

N-亚硝基二甲胺合成路线

N-亚硝基二甲胺上下游产品

N-亚硝基二甲胺上游产品

N-亚硝基二甲胺下游产品

N-亚硝基二甲胺制备

1. 将245g盐酸二甲胺和盐酸搅拌加热至70-75℃，加入235g亚硝酸钠在150ml水中的浆状液，同时添加盐酸使反应物恰呈酸性。加毕，加热2h，然后蒸馏至近干，加水再蒸干，将馏出物合并用300g碳酸钾使之饱和，取上层减压分馏，得近200gN-亚硝基二甲胺，收率近90%。

2. 烟草：BU，2。

N-亚硝基二甲胺文献

[Effect of cordyceps polysaccharide on lipid peroxidation of rats with dimethylnitrosamine-induced liver fibrosis].

Zhongguo Zhong Yao Za Zhi 38(3) , 391-6, (2013)

To observe the pharmacological effect of Cordyceps polysaccharide on dimethylnitrosamine (DMN)-induced liver fibrosis in rats.DMN rat liver fibrosis model was established and divided into the normal g...

Relationship between organic precursors and N-nitrosodimethylamine (NDMA) formation in tropical water sources.

J. Water Health 12(4) , 736-46, (2014)

The presence of organic compounds in water sources is one of the concerns in water treatment. They are potential precursors of disinfection byproducts (DBPs) and thus induce health problems in humans....

Developing structure-activity relationships for the prediction of hepatotoxicity.

Chem. Res. Toxicol. 23 , 1215-22, (2010)

Drug-induced liver injury is a major issue of concern and has led to the withdrawal of a significant number of marketed drugs. An understanding of structure-activity relationships (SARs) of chemicals ...

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N-亚硝基二甲胺相关知识

n-亚硝基二甲胺用来做什么用？

2019-07-27 20:52:43

N-亚硝基二甲胺（英语：N-Nitrosodimethylamine，简称NDMA），结构简式：（CH3)2N(NO)，它是一种半挥发性有机化学品，气味与味道很弱，易溶于溶于水、醇、醚等，是一种有毒物品，具有强肝脏毒性，对人类很可能有致癌性。主要用于火箭燃料、抗氧剂等制造。又名二甲基亚硝胺。N-亚...