Big Endothelin-1 (1-39), porcine

Big Endothelin-1 (1-39), porcine用途

Big Endothelin-1 (1-39), porcine 是内皮素-1 (endothelin-1) 的前体。Endothelin-1 (ET-1) 是一种有效的升压肽。Big Endothelin-1 (1-39), porcine 在体内具有类似的升压作用。

Big Endothelin-1 (1-39), porcine名称

[ CAS 号 ]:
120796-99-8

[ 英文名 ]:
Big Endothelin-1 (1-39), porcine

[英文别名 ]:

Big Endothelin-1 (1-39), porcine生物活性

[ 描述 ]:

Big Endothelin-1 (1-39), porcine 是内皮素-1 (endothelin-1) 的前体。Endothelin-1 (ET-1) 是一种有效的升压肽。Big Endothelin-1 (1-39), porcine 在体内具有类似的升压作用。

[ 相关类别 ]:

研究领域 >> 心血管疾病

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 血管加压素受体

[体外研究]

内皮素-1(ET-1)是一种有效的内皮细胞衍生的21氨基酸肽,具有强大的血管收缩特性,可能参与血压和局部血流的调节[1]。

[体内研究]

大内皮素-1(1-39),猪,由cDNA推断的内皮素-1的前体,在体内也有类似的升压作用[1]。

[参考文献]

[1]. A Hoffman, et al. Opposite effects of endothelin-1 and Big-endothelin-(1-39) on renal function in rats. Eur J Pharmacol. 1990 Jul 17;182(3):603-6.

Big Endothelin-1 (1-39), porcine物理化学性质

[ 分子式 ]:
C₁₉₃H₂₈₉N₄₉O₅₈S₅

[ 储存条件 ]:
−20°C

Big Endothelin-1 (1-39), porcine安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

Big Endothelin-1 (1-39), porcine文献

A novel potent vasoconstrictor peptide produced by vascular endothelial cells.

Nature 332 , 411, (1988)

An endothelium-derived 21-residue vasoconstrictor peptide, endothelin, has been isolated, and shown to be one of the most potent vasoconstrictors known. Cloning and sequencing of preproendothelin comp...

Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium-derived vasoconstrictor peptide, endothelin: identity of human and porcine endothelin.

FEBS Lett. 231 , 440, (1988)

A cDNA encoding a human endothelium-derived vasoconstrictor peptide, endothelin, was isolated from a human placenta cDNA library. The nucleotide sequence of this cDNA clone showed that the primary str...

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