Big endothelin-1 (rat 1-39)

Big endothelin-1 (rat 1-39)用途

Big endothelin-1 (rat 1-39) 是含有 39 个残基的肽。Big endothelin-1 (rat 1-39) 诱导清醒的 Sprague-Dawley 大鼠利尿和利钠反应。Big endothelin-1 (rat 1-39) 能使小鼠血压升高。

Big endothelin-1 (rat 1-39)名称

[ CAS 号 ]:
135842-15-8

[ 英文名 ]:
Big endothelin-1 (rat 1-39)

[英文别名 ]:

Big endothelin-1 (rat 1-39)生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 心血管疾病

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Hoffman A, et al. Opposite effects of endothelin-1 and Big-endothelin-(1-39) on renal function in rats. Eur J Pharmacol. 1990 Jul 17;182(3):603-6.

Big endothelin-1 (rat 1-39)物理化学性质

[ 分子式 ]:
C₁₉₂H₂₉₂N₅₀O₅₈S₅

[ 分子量 ]:
4389

[ 储存条件 ]:
−20°C

Big endothelin-1 (rat 1-39)安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

Big endothelin-1 (rat 1-39)文献

Chronic endothelin receptor blockade attenuates progressive ventricular dilation and improves cardiac function in rats with myocardial infarction: possible involvement of myocardial endothelin system in ventricular remodeling.

Circulation 96(11) , 3963-73, (1997)

Left ventricular dilatation after myocardial infarction is associated with impaired ventricular function and heart failure and has important implications for survival. The purpose of this study was to...

Phosphoramidon blocks the pressor activity of porcine big endothelin-1-(1-39) in vivo and conversion of big endothelin-1-(1-39) to endothelin-1-(1-21) in vitro.

Proc. Natl. Acad. Sci. U. S. A. 88(3) , 703-7, (1991)

In porcine aortic endothelial cells, the 21-amino acid peptide endothelin-1 (ET-1) is formed from a 39-amino acid intermediate called "big endothelin-1" (big ET-1) by a putative ET-converting enzyme (...

Phosphoramidon blocks big-endothelin-1 but not endothelin-1 enhancement of vascular permeability in the rat.

Br. J. Pharmacol. 107(4) , 996-1000, (1992)

1. Changes in vascular permeability following intravenous injections of human big-endothelin-1 (big-ET-1) and endothelin-1 (ET-1) were measured by extravasation of Evans blue dye (EB, 20 mg kg-1) in s...

更多文献