达诺沙星

达诺沙星用途

Danofloxacin 是一种具有口服活性第的三代氟喹诺酮抗菌剂,对大多数革兰氏阴性和革兰氏阳性细菌,支原体和衣原体物种具有广谱的活性,并通过抑制细菌的 DNA 回转酶发挥抗菌作用。Danofloxacinh 可用于牛,猪和鸡呼吸道疾病的研究。

达诺沙星名称

[ CAS 号 ]:
112398-08-0

[ 中文名 ]:
达氟沙星

[ 英文名 ]:
Danofloxacine

[中文别名 ]:

达诺沙星

[英文别名 ]:

danofloxacin

达诺沙星生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 细胞周期/DNA损伤 >> DNA/RNA合成

信号通路 >> 抗感染 >> 细菌

[参考文献]

[1]. Erjie Tian, et al. Population Pharmacokinetics for Danofloxacin in the Intestinal Contents of Healthy and Infected Chickens. J Vet Pharmacol Ther. 2019 Sep;42(5):556-563.

[2]. Xia Xiao, et al. Comparative Pharmacokinetics of Danofloxacin in Healthy and Pasteurella Multocida Infected Ducks. J Vet Pharmacol Ther. 2018 Dec;41(6):912-918.

达诺沙星物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
569.3±50.0 °C at 760 mmHg

[ 熔点 ]:
268-272ºC

[ 分子式 ]:
C₁₉H₂₀FN₃O₃

[ 分子量 ]:
357.379

[ 闪点 ]:
298.1±30.1 °C

[ 精确质量 ]:
357.148865

[ PSA ]:
65.78000

[ LogP ]:
1.20

[ 外观性状 ]:
无色粉末

[ 蒸汽压 ]:
0.0±1.6 mmHg at 25°C

[ 折射率 ]:
1.679

[ 储存条件 ]:
2-8℃，充氩保存

[ 水溶解性 ]:
Soluble in water, acetic acid and DMSO

达诺沙星安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn,Xi

[ 风险声明 (欧洲) ]:
20/21/22-36/37/38

[ 安全声明 (欧洲) ]:
22-24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

达诺沙星合成路线

详细合成路线

达诺沙星上下游产品

达诺沙星上游产品

达诺沙星下游产品

达诺沙星文献

Multiresidue determination of fluoroquinolones in poultry muscle and kidney according to the regulation 2002/657/EC. A systematic comparison of two different approaches: Liquid chromatography coupled to high-resolution mass spectrometry or tandem mass spectrometry.

J. Chromatogr. A. 1379 , 83-91, (2015)

This work involved the optimization and validation of two methods according to the Commission Decision 2002/657/EC directives for determining fluoroquinolones residues in samples of poultry muscle and...

Simultaneous determination of 38 veterinary antibiotic residues in raw milk by UPLC-MS/MS.

Food Chem. 181 , 119-26, (2015)

A selective and rapid method has been developed to determine, simultaneously, 38 veterinary antibiotic residues in raw milk by ultra-high-performance liquid chromatography-tandem mass spectrometry (UP...

Decay mechanisms of protonated 4-quinolone antibiotics after electrospray ionization and ion activation.

J. Am. Soc. Mass Spectrom. 25(11) , 1974-86, (2014)

This study presents a detailed experimental investigation of charge isomers of protonated 4-quinolone antibiotics molecules formed during electrospray ionization (ESI) with proposed dissociation mecha...

更多文献