依诺沙星
依诺沙星用途
广谱抗菌素,用于治疗革兰阴性及阳性细菌引起的泌尿、耳、鼻、喉及浅表化脓性疾患等多种感染
【用途二】
喹诺酮类广谱抗感染药,对革兰阳性和阴性菌及葡萄糖非发酵菌有抗菌作用。适用于治疗呼吸系统感染,消化道感染,泌尿生殖系统感染以及皮肤、耳鼻眼喉感染,妇科疾病感染
【用途三】
该品为第三代喹诺酮类药。体内抗菌作用较氟哌酸强2-9倍。临床用球必尿系统、呼吸系统、消化系统、耳鼻喉、皮肤及软组织感染等。
依诺沙星名称
[ CAS 号 ]:
74011-58-8
[ 中文名 ]:
依诺沙星
[ 英文名 ]:
Enoxacin
[中文别名 ]:
[英文别名 ]:
- MFCD00133308
- enoram
- Enoxacin
- FLUMARK
- Abenox
- ENX
- Gyramid
- Enoxor
- ci919
- at-2266
依诺沙星生物活性
[ 描述 ]:
[ 相关类别 ]:
[参考文献]
[相关活性小分子]
依诺沙星物理化学性质
[ 密度 ]:
1.4±0.1 g/cm3
[ 沸点 ]:
569.9±50.0 °C at 760 mmHg
[ 熔点 ]:
220-224ºC
[ 分子式 ]:
C15H17FN4O3
[ 分子量 ]:
320.319
[ 闪点 ]:
298.4±30.1 °C
[ 精确质量 ]:
320.128479
[ PSA ]:
87.46000
[ LogP ]:
0.55
[ 外观性状 ]:
灰白色至黄色晶体
[ 蒸汽压 ]:
0.0±1.6 mmHg at 25°C
[ 折射率 ]:
1.599
[ 储存条件 ]:
2-8°C
依诺沙星毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- QN2800000
- CHEMICAL NAME :
- 1,8-Naphthyridine-3-carboxylic acid, 1,4-dihydro-1-ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-
- CAS REGISTRY NUMBER :
- 74011-58-8
- LAST UPDATED :
- 199806
- DATA ITEMS CITED :
- 15
- MOLECULAR FORMULA :
- C15-H17-F-N4-O3
- MOLECULAR WEIGHT :
- 320.36
- WISWESSER LINE NOTATION :
- T66 BV EN GNJ CVQ E2 IF H- DT6M DNTJ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >2 gm/kg
- TOXIC EFFECTS :
- Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia Skin and Appendages - hair
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 236 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >4 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 3600 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 327 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- >1600 mg/kg
- TOXIC EFFECTS :
- Behavioral - food intake (animal) Gastrointestinal - hypermotility, diarrhea
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Primate - monkey
- DOSE/DURATION :
- >1600 mg/kg
- TOXIC EFFECTS :
- Behavioral - food intake (animal) Gastrointestinal - hypermotility, diarrhea
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 90 gm/kg/30D-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - changes in bladder weight Blood - changes in leukocyte (WBC) count Nutritional and Gross Metabolic - changes in calcium
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 273 gm/kg/26W-I
- TOXIC EFFECTS :
- Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - changes in testicular weight
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1680 mg/kg/4W-I
- TOXIC EFFECTS :
- Skin and Appendages - dermatitis, other (after systemic exposure) Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 91 gm/kg
- SEX/DURATION :
- male 13 week(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females) Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 11 gm/kg
- SEX/DURATION :
- female 7-17 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
MUTATION DATA
- TYPE OF TEST :
- Mutation in microorganisms
- TEST SYSTEM :
- Bacteria - Salmonella typhimurium
- DOSE/DURATION :
- 200 ng/plate
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 281,207,1992
依诺沙星安全信息
[ 危害码 (欧洲) ]:
Xi
[ 风险声明 (欧洲) ]:
36/37/38
[ 安全声明 (欧洲) ]:
26-36/37
[ WGK德国 ]:
2
[ RTECS号 ]:
QN2800000
[ 海关编码 ]:
29335995
依诺沙星合成路线
依诺沙星上下游产品
依诺沙星上游产品
依诺沙星下游产品
依诺沙星制备
方法1:以2,6-二羟基-5-氟烟酰胺为原料,经氯化、酯化、与乙酰哌嗪缩合、与3-乙胺基丙酸乙酯缩合、环化、脱氢、水解得产品。该路线条件温和,路线较短,但需特殊试剂四氯苯醌。国内目前主要采用该法。
方法2:另一条路线是以2,6-二氯-3-硝基吡啶为原料,经与乙氧羰基哌嗪缩合后,再经氨解、乙酰化、还原、重氮化、氟化、水解、与EMME缩合、环合乙基化、水解得产品。该法氟化反应不易控制、环化需高温,工艺条件苛刻。
依诺沙星海关
[ 海关编码 ]: 29335995
推荐生产厂家/供应商:
公司名:上海吉至生化科技有限公司
区域:上海市奉贤区
价格:
¥148.0/1g
¥528.0/5g
联系人:刘佳
产品详情:依诺沙星
公司名:上海源溪生物科技有限公司
区域:上海市浦东新区
价格:
¥需询单/1g
联系人:赖经理
产品详情:Enoxacin
公司名:上海脉铂医药科技有限公司
区域:上海市嘉定区
价格:
¥689.0/50mg
¥489.0/1g
¥需询单/1g
¥需询单/1g
联系人:李先生
产品详情:Enoxacin (Penetrex)
公司名:上海创赛科技有限公司
区域:上海市嘉定区
价格:
¥150.0/1g
¥291.0/5g
¥782.0/25g
¥2831.0/100g
联系人:夏言
产品详情:[Perfemiker]依诺沙星,98%
公司名:上海阿拉丁生化科技股份有限公司
区域:上海市浦东新区
价格:
¥399.9/1ml
¥需询单/1g
¥需询单/1g
¥需询单/1g
联系人:阿拉丁李高志
产品详情:依诺沙星
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相关化合物
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标题:依诺沙星_用途_密度_熔点_依诺沙星CAS号【74011-58-8】_化源网 地址:https://www.chemsrc.com/amp/cas/74011-58-8_237270.html