2-Methoxyidazoxan monohydrochloride

2-Methoxyidazoxan monohydrochloride用途

2-甲氧基咪唑烷单盐酸盐(RX821002盐酸盐)是一种高选择性α2-肾上腺素受体拮抗剂,咪唑啉拮抗剂作用很小或没有。RX 821002对(豚鼠)α2D肾上腺素受体(pKd 9.7)的亲和力明显高于(兔子)α2A肾上腺素受体(pKd 8.2)[1][2]。

2-Methoxyidazoxan monohydrochloride名称

[ CAS 号 ]:
109544-45-8

[ 中文名 ]:
2-(2-甲氧基-2,3-二氢-1,4-苯并二氧杂环己-2-基)-4,5-二氢-1H-咪唑盐酸盐

[ 英文名 ]:
RX 821002 hydrochloride

[英文别名 ]:

RX 821002 hydrochloride

2-Methoxyidazoxan monohydrochloride生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 肾上腺素能受体

研究领域 >> 神经疾病

[体内研究]

2-甲氧基咪唑嗪单盐酸盐(1 mg/kg)可增强新环境中的运动能力,尤其是在新生大鼠腹侧海马损伤(NVHL)中。RX82100对运动具有双相效应,包括增强之前的初始减少[3]。

[参考文献]

[1]. Head GA. Importance of imidazoline receptors in the cardiovascular actions of centrally acting antihypertensive agents. Ann N Y Acad Sci. 1995;763:531-540.

[2]. Trendelenburg AU, et al. Antagonists that differentiate between alpha 2A-and alpha 2D-adrenoceptors. Naunyn Schmiedebergs Arch Pharmacol. 1996;353(3):245-249.

[3]. Sandner G, et al. Effects of caffeine or RX821002 in rats with a neonatal ventral hippocampal lesion. Front Behav Neurosci. 2014;8:15. Published 2014 Jan 28.

2-Methoxyidazoxan monohydrochloride物理化学性质

[ 分子式 ]:
C₁₂H₁₅ClN₂O₃

[ 分子量 ]:
270.71200

[ 精确质量 ]:
270.07700

[ PSA ]:
52.08000

[ LogP ]:
1.36860

[ 储存条件 ]:
室温

2-Methoxyidazoxan monohydrochlorideMSDS

详细MSDS(安全技术说明书)

2-Methoxyidazoxan monohydrochloride安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26

[ 危险品运输编码 ]:
NONH for all modes of transport

2-Methoxyidazoxan monohydrochloride文献

Role of the bed nucleus of the stria terminalis in the cardiovascular responses to acute restraint stress in rats.

Stress 12(3) , 268-78, (2009)

The aim of this work was to test the hypothesis that the bed nucleus of the stria terminalis (BST) and noradrenergic neurotransmission therein mediate cardiovascular responses to acute restraint stres...

Disruption of noradrenergic transmission and the behavioural response to a novel environment in NK1R-/- mice.

Eur. J. Neurosci. 25(4) , 1195-204, (2007)

The behaviour of neurokinin-1-receptor gene knockout (NK1R-/-) mice, which lack functional, substance P-preferring receptors, resembles that of NK1R+/+ mice treated with an antidepressant. Because all...

Adrenergic mechanisms of the Kölliker-Fuse/A7 area on the control of water and sodium intake.

Neuroscience 164(2) , 370-9, (2009)

The blockade of serotoninergic receptors with methysergide or the activation of alpha(2)-adrenoceptors with moxonidine into the lateral parabrachial nucleus (LPBN) increases water and 0.3 M NaCl intak...

更多文献