特立氟胺

特立氟胺用途

(E/Z)-Teriflunomide((E/Z)-A77 1726)是来氟米特(HY-B0083)的活性代谢物。来氟米特是一种免疫调节剂,可通过抑制线粒体酶二氢乳清酸脱氢酶(DHODH)发挥作用。来氟米特可用于类风湿性关节炎(RA)的研究[1]。

特立氟胺名称

[ CAS 号 ]:
108605-62-5

[ 中文名 ]:
2-氰基-3-羟基-N-[4-(三氟甲基)苯基]-2-丁烯酰胺

[ 英文名 ]:
teriflunomide

[中文别名 ]:

特立氟胺

[英文别名 ]:

Teriflunomide

特立氟胺生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 感染

研究领域 >> 炎症/免疫

特立氟胺物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
363.0±42.0 °C at 760 mmHg

[ 分子式 ]:
C₁₂H₉F₃N₂O₂

[ 分子量 ]:
270.207

[ 闪点 ]:
173.3±27.9 °C

[ 精确质量 ]:
270.061615

[ PSA ]:
73.12000

[ LogP ]:
0.71

[ 外观性状 ]:
白色固体

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 折射率 ]:
1.552

[ 储存条件 ]:
+2C to +8C

特立氟胺安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
22

[ 危险品运输编码 ]:
NONH for all modes of transport

特立氟胺文献

Hepatic cytochrome P450s attenuate the cytotoxicity induced by leflunomide and its active metabolite A77 1726 in primary cultured rat hepatocytes.

Toxicol. Sci. 122(2) , 579-86, (2011)

The Black Box Warning section of the U.S. drug label for leflunomide was recently updated to include stronger warnings about potential hepatotoxicity from this novel anti-arthritis drug. Because metab...

Respiratory syncytial virus inhibits lung epithelial Na+ channels by up-regulating inducible nitric-oxide synthase.

J. Biol. Chem. 284(11) , 7294-306, (2009)

Respiratory syncytial virus (RSV) infection has been shown to reduce Na+-driven alveolar fluid clearance in BALB/c mice in vivo. To investigate the cellular mechanisms by which RSV inhibits amiloride-...

Induction of EMT-like phenotypes by an active metabolite of leflunomide and its contribution to pulmonary fibrosis.

Cell Death Differ. 17(12) , 1882-95, (2010)

Drug-induced interstitial lung disease (ILD), particularly pulmonary fibrosis, is a serious clinical concern and myofibroblasts have been suggested to have a major role, with it recently being reveale...

更多文献