β-Interleukin I (163-171), human

β-Interleukin I (163-171), human用途

β-白细胞介素I(163-171),人,人IL-1β肽的免疫刺激片段,是T细胞激活剂。β-白细胞介素I(163-171),人不是IL-1β的IL-1R结合域。β-白细胞介素I(163-171),人是一种有效的佐剂,在多种实验中增强免疫反应。情况[1][3][4]。

β-Interleukin I (163-171), human名称

[ CAS 号 ]:
106021-96-9

[ 英文名 ]:
β-Interleukin I (163-171), human

[英文别名 ]:

β-Interleukin I (163-171)

β-Interleukin I (163-171), human生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

[体外研究]

β-白介素I(163-171),人(12.5-400μg/mL,72小时)刺激小鼠胸腺细胞增殖[6]。

[体内研究]

β-白细胞介素I(163-171),人(50μg,每天,BALB/c小鼠模型的免疫原性较差的纤维肉瘤(CE-2))诱导了一致但有限的肿瘤生长抑制[2]。β-白细胞介素I(163-171),人(1μmol/kg,静脉注射)与T依赖性抗原SRBC一起增加对抗原的主要免疫应答[3]。

[参考文献]

[1]. Nencioni L, et al. In vivo immunostimulating activity of the 163-171 peptide of human IL-1 beta. J Immunol. 1987 Aug 1;139(3):800-4.

[2]. Forni G, et al. Ability of a nonapeptide of the human IL-1 beta to recruit anti-tumor reactivity in recipient mice. J Immunol. 1989 Jan 15;142(2):712-8.

[3]. Boraschi D, , et al. In vivo stimulation and restoration of the immune response by the noninflammatory fragment 163-171 of human interleukin 1 beta. J Exp Med. 1988 Aug 1;168(2):675-86.

[4]. Tagliabue, A., et al. (1997). Interleukin 1 and Its Synthetic Peptide 163–171 as Vaccine Adjuvants. Vaccine Design pp 167-173.

[5]. Boraschi D, et al. Binding and internalization of the 163-171 fragment of human IL-1 beta. Cytokine. 1992 May;4(3):201-4.

[6]. Bajpai K, et al. Immunomodulating activity of analogs of noninflammatory fragment 163-171 of human interleukin-1beta. Immunopharmacology. 1998 Jan;38(3):237-45.

β-Interleukin I (163-171), human物理化学性质

[ 密度 ]:
1.419g/cm3

[ 沸点 ]:
1682.6ºC at 760mmHg

[ 分子式 ]:
C₃₉H₆₄N₁₂O₁₉

[ 分子量 ]:
1004.99000

[ 闪点 ]:
971.4ºC

[ 精确质量 ]:
1004.44000

[ PSA ]:
540.45000

[ 蒸汽压 ]:
0mmHg at 25°C

[ 折射率 ]:
1.573

[ 储存条件 ]:
-20°C

β-Interleukin I (163-171), human安全信息

[ WGK德国 ]:
3

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