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微囊藻毒素LR

微囊藻毒素LR用途

Microcystin-LR是小非核糖体肽, Microcystin-LR是由蓝藻产生的毒素, 是最毒的微囊藻毒素, Microcystin-LR在肝细胞中抑制蛋白磷酸酶1型和2A型（PP1和PP2A）活性。

微囊藻毒素LR名称

[ CAS 号 ]:
101043-37-2

[ 中文名 ]:
微囊藻毒素(LR亚型)

[ 英文名 ]:
Microcystin-LR

[中文别名 ]:

[英文别名 ]:

akerstox
TOXIN,BLUE-GREENALGA
EINECS 200-659-6
Microcystin-LR
microcystin-lr solution
toxin-lr
microcystin LR
MFCD00131607
5-L-Arginine-cyanoginosin
5-L-Arginine-microcystin LA

微囊藻毒素LR生物活性

[ 描述 ]:

Microcystin-LR 是蛋白磷酸酶 1 型和 2A 型 ((PP1/2A)) 的有效抑制剂,其 IC50 值分别为 1.7 nM,0.04 nM。

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> 磷酸酶

研究领域 >> 炎症/免疫

天然产物 >> 其他

多肽产品

[ 靶点 ]

IC50: 1.7 nM (PP1), 0.04 nM (PP2A)[1].

[体外研究]

微囊藻毒素是由于水体富营养化而由蓝藻水华产生的有毒分子[2]。微囊藻毒素-LR证明是1型(IC50 = 1.7nM)和2A型(IC50 = 0.04nM)蛋白磷酸酶的有效抑制剂。在相同条件下,微囊藻毒素-LR抑制1型和2A型磷酸酶的活性比冈田酸的效力高10倍。发现稀释的哺乳动物细胞提取物中的2A型蛋白磷酸酶被0.5nM微囊藻毒素-LR完全抑制,而1型蛋白磷酸酶仅在该浓度下受轻微影响[1]。

[参考文献]

[1]. Honkanen RE, et al. Characterization of microcystin-LR, a potent inhibitor of type 1 and type 2A protein phosphatases. J Biol Chem. 1990 Nov 15;265(32):19401-4.

[2]. Lone Y, et al. Microcystin-LR Induced Immunotoxicity in Mammals. J Toxicol. 2016:8048125.

[相关活性小分子]

微囊藻毒素LR物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 分子式 ]:
C₄₉H₇₄N₁₀O₁₂

[ 分子量 ]:
995.172

[ 闪点 ]:
11 °C

[ 精确质量 ]:
994.548767

[ PSA ]:
340.64000

[ LogP ]:
-1.54

[ 外观性状 ]:
solid film

[ 折射率 ]:
1.598

[ 储存条件 ]:
库房低温,通风,干燥,与食品原料分开存放

[ 水溶解性 ]:
ethanol: 1 mg/mL

微囊藻毒素LRMSDS

微囊藻毒素LR毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GT2810000

CHEMICAL NAME :: Cyanoginosin LA, 5-L-arginine-

CAS REGISTRY NUMBER :: 101043-37-2

LAST UPDATED :: 199612

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C49-H74-N10-O12

MOLECULAR WEIGHT :: 995.33

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 50 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 26,603,1988

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 50 ug/kg

TOXIC EFFECTS :: Cardiac - other changes Liver - hepatitis (hepatocellular necrosis), zonal Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

REFERENCE :: TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 8,221,1988

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 18 mg/m3/10M

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 28,605,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 32500 ng/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Kidney, Ureter, Bladder - other changes Skin and Appendages - hair

REFERENCE :: JEPOEC Journal of Environmental Pathology, Toxicology and Oncology. (Chem-Orbital, POB 134, Park Forest, IL 60466) V.5(4)- 1984- Volume(issue)/page/year: 9(3),221,1989

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 60 ug/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay) Skin and Appendages - hair

REFERENCE :: SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year: 220,1383,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5200 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 63,215,1987 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2205 ug/kg/6W-I

TOXIC EFFECTS :: Liver - other changes Liver - changes in liver weight Related to Chronic Data - death

REFERENCE :: AJBSAM Australian Journal of Biological Sciences. (Commonwealth Scientific and Industrial Research Organization, 314 Albert St., E. Melbourne, Vic. 3002, Australia) V.6- 1953- Volume(issue)/page/year: 31,209,1978

微囊藻毒素LR安全信息

[ 符号 ]:

GHS02, GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H301-H311-H331-H370

[ 警示性声明 ]:
P210-P260-P280-P301 + P310-P311

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US)

[ 危害码 (欧洲) ]:
T+

[ 风险声明 (欧洲) ]:
26/27/28-36/37/38-43

[ 安全声明 (欧洲) ]:
S26;S45;S36/S37/S39

[ 危险品运输编码 ]:
UN 2811 6.1/PG 1

[ WGK德国 ]:
3

[ RTECS号 ]:
GT2810000

[ 危险类别 ]:
6.1

微囊藻毒素LR合成路线

微囊藻毒素LR文献

Growth inhibition and microcystin degradation effects of Acinetobacter guillouiae A2 on Microcystis aeruginosa.

Res. Microbiol. 166(2) , 93-101, (2015)

Strain A2 with algicidal activity against Microcystis aeruginosa was isolated and identified with the genus Acinetobacter on the basis of phenotypic tests and 16S rRNA gene analysis. It was identified...

Protein kinase C and P2Y12 take center stage in thrombin-mediated activation of mammalian target of rapamycin complex 1 in human platelets.

J. Thromb. Haemost. 12(5) , 748-60, (2014)

Rapamycin, an inhibitor of mammalian target of rapamycin complex-1 (mTORC1), reduces platelet spreading, thrombus stability, and clot retraction. Despite an important role of mTORC1 in platelet functi...

Sensitive detection of microcystin-LR by using a label-free electrochemical immunosensor based on Au nanoparticles/silicon template/methylene blue nanocomposite.

J. Nanosci. Nanotechnol. 13(12) , 8245-52, (2013)

A label-free electrochemical immunosensor, based on a gold nanoparticles (Au NPs)/silicon template/methylene blue (MB)/chitosan (CHIT) nanocomposite-modified electrode, was fabricated for the ultrasen...

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