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天仙子胺

天仙子胺用途

L-Hyoscyamine是莨菪烷生物碱,为阿托品的左旋同分异构体。

天仙子胺名称

[ CAS 号 ]:
101-31-5

[ 中文名 ]:
莨菪碱

[ 英文名 ]:
Hyoscyamine

[中文别名 ]:

[英文别名 ]:

CYSTOSPAZ
L-Hyoscyamine
3a-Tropanyl S-(-)-Tropate
scopolamine HCl
SCOPINE TROPATE
Levsin
(S)-(-)-hyoscyamine
SCOPINE TROPATE HYDROCHLORIDE
MFCD00067306
(S)-atropine

天仙子胺生物活性

[ 描述 ]:

L-Hyoscyamine是莨菪烷生物碱,为阿托品的左旋同分异构体。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 由mAChR

信号通路 >> 神经信号通路 >> mAChR

天然产物 >> 生物碱

研究领域 >> 神经疾病

[参考文献]

[1]. http://www.drugbank.ca/drugs/DB00424

[相关活性小分子]

天仙子胺物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
429.8±45.0 °C at 760 mmHg

[ 熔点 ]:
108.5ºC

[ 分子式 ]:
C₁₇H₂₃NO₃

[ 分子量 ]:
289.369

[ 闪点 ]:
213.7±28.7 °C

[ 精确质量 ]:
289.167786

[ PSA ]:
49.77000

[ LogP ]:
1.53

[ 外观性状 ]:
白色结晶粉末

[ 蒸汽压 ]:
0.0±1.1 mmHg at 25°C

[ 折射率 ]:
1.581

[ 储存条件 ]:
2-8°C

天仙子胺MSDS

天仙子胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NH0875000

CHEMICAL NAME :: Hyoscyamine, (-)-

CAS REGISTRY NUMBER :: 101-31-5

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C17-H23-N-O3

MOLECULAR WEIGHT :: 289.41

WISWESSER LINE NOTATION :: T56 A ANTJ A1 GOVYR&1Q -L

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 1471 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970 Volume(issue)/page/year: 2,73,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 95 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 24,138,1965 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - A1029 No. of Facilities: 68 (estimated) No. of Industries: 1 No. of Occupations: 6 No. of Employees: 2770 (estimated)

天仙子胺安全信息

[ 危害码 (欧洲) ]:
T+: Very toxic;

[ 风险声明 (欧洲) ]:
R26/28

[ 安全声明 (欧洲) ]:
24-45

[ 危险品运输编码 ]:
UN 1544 6

[ WGK德国 ]:
3

[ RTECS号 ]:
NH0875000

[ 海关编码 ]:
2933990090

天仙子胺合成路线

天仙子胺上下游产品

天仙子胺上游产品

天仙子胺下游产品

天仙子胺制备

颠茄浸膏经提取精制而得。

天仙子胺海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

天仙子胺文献

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Life Sci. 93(1) , 17-23, (2013)

Recombinant systems have been used for evaluating the properties of G-protein-coupled receptors (GPCRs) on the assumption of cell surface expression. However, many GPCRs, including muscarinic acetylch...

Sudden unexpected death in a mouse model of Dravet syndrome.

J. Clin. Invest. 123(4) , 1798-808, (2013)

Sudden unexpected death in epilepsy (SUDEP) is the most common cause of death in intractable epilepsies, but physiological mechanisms that lead to SUDEP are unknown. Dravet syndrome (DS) is an infanti...

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