青霉素V结构式
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常用名 | 青霉素V | 英文名 | Penicillin-V |
|---|---|---|---|---|
| CAS号 | 87-08-1 | 分子量 | 350.389 | |
| 密度 | 1.5±0.1 g/cm3 | 沸点 | 681.4±55.0 °C at 760 mmHg | |
| 分子式 | C16H18N2O5S | 熔点 | 120 - 128ºC | |
| MSDS | N/A | 闪点 | 365.9±31.5 °C |
青霉素V用途青霉素V(苯氧甲基青霉素)是一种有效的口服抗生素。青霉素V对链球菌、艰难梭菌和金黄色葡萄球菌具有抗菌活性。青霉素V具有研究中耳炎、鼻窦炎、咽炎和扁桃体炎的潜力[1][2][3][4]。 |
| 中文名 | 青霉素V |
|---|---|
| 英文名 | phenoxymethylpenicillin |
| 中文别名 | 苯氧甲基青霉素 | 青黴素V |
| 英文别名 | 更多 |
| 描述 | 青霉素V(苯氧甲基青霉素)是一种有效的口服抗生素。青霉素V对链球菌、艰难梭菌和金黄色葡萄球菌具有抗菌活性。青霉素V具有研究中耳炎、鼻窦炎、咽炎和扁桃体炎的潜力[1][2][3][4]。 |
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| 相关类别 | |
| 体外研究 | 青霉素V(0.002-8.0mg/L)抑制链球菌的生长,最低抑制浓度(MIC)为0.004-0.008mg/L[2]。青霉素V(0.002-8.0 mg/L)对艰难梭菌具有抗菌活性,MIC50值为4.0 mg/L,MIC90值为8.0 g/L[3]。青霉素V(0.004-0.063 mg/L；18 h)抑制金黄色葡萄球菌的生长,MIC值为0.016 mg/L[4]。 |
| 体内研究 | 青霉素V(0.063-0.25mg/kg；s.c.)抑制小鼠大腿肌肉中金黄色葡萄球菌的生长[4]。青霉素V(2 mg/kg；s.c.)的血浆半衰期(61 min)和平均AUC(0.47 mg/L·h)[4]。青霉素V(100mg/kg；每天一次,持续5天)可避免大鼠急性化脓性中耳炎(AOM)的暴发性感染[5]。动物模型：无特异性病原体(SPF)雄性瑞士小鼠(20-25 g)接种金黄色葡萄球菌[4]剂量：0.063、0.13、0.25 mg/kg给药：S.c.结果：与对照组(3.5×107计数/mL)相比,0.25 g/kg剂量下的CFU数量(1.34×107计数/mL)减少。 |
| 参考文献 |
| 密度 | 1.5±0.1 g/cm3 |
|---|---|
| 沸点 | 681.4±55.0 °C at 760 mmHg |
| 熔点 | 120 - 128ºC |
| 分子式 | C16H18N2O5S |
| 分子量 | 350.389 |
| 闪点 | 365.9±31.5 °C |
| 精确质量 | 350.093628 |
| PSA | 121.24000 |
| LogP | 1.88 |
| 外观性状 | 白色至灰白色结晶粉末 |
| 蒸汽压 | 0.0±2.2 mmHg at 25°C |
| 折射率 | 1.651 |
| 储存条件 | −20°C |
| 稳定性 | Stable. Combustible. Incompatible with strong oxidizing agents. |
| 水溶解性 | Very slightly soluble in water, soluble in ethanol (96 per cent). |
| 青霉素V上游产品 8 | |
|---|---|
| 青霉素V下游产品 3 | |
| 海关编码 | 3003101300 |
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| penicillin-V |
| Oracillin |
| Pen-vee-oral |
| Fenospen |
| (2S,5R,6R)-3,3-Dimethyl-7-oxo-6-[(phenoxyacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
| Penicillin phenoxymethyl |
| (2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(2-phenoxyacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
| PenicillinV |
| Phenocillin |
| Beromycin |
| (2S,5R,6R)-3,3-dimethyl-7-oxo-6-{[(phenyloxy)acetyl]amino}-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
| Phenopenicillin |
| Acipen-V |
| Phenomycilline |
| Phenospen |
| V-Cillin |
| [2S-(2a,5a,6b)]-3,3-Dimethyl-7-oxo-6-[(phenoxy acetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid |
| Orocillin |
| penicillin V |
| 6-phenoxyacetamidopenicillanic acid |
| dowpen v-k |
| 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[(2-phenoxyacetyl)amino]-, (2S,5R,6R)- |
| 4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[(phenoxyacetyl)amino]-, (2S,5R,6R)- |
| penicillin VK |
| Phenoxymethylpenicillin |
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