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CS 2100

更新时间：2025-09-13 00:01:38

CS 2100结构式	常用名	CS 2100	英文名	CS 2100
	CAS号	913827-99-3	分子量	461.53
	密度	N/A	沸点	N/A
	分子式	C₂₅H₂₃N₃O₄S	熔点	N/A
	MSDS	N/A	闪点	N/A

CS 2100用途

CS-2100(化合物10b)是一种有效、选择性、口服活性和S1P3保留的S1P1激动剂,对人S1P1的EC50为4.0 nM。CS-2100对HvGR的ID50(感染剂量)为0.407 mg/kg的大鼠显示出体内免疫抑制效果【1】。

英文名	1-({4-Ethyl-5-[5-(4-phenoxyphenyl)-1,2,4-oxadiazol-3-yl]-2-thieny l}methyl)-3-azetidinecarboxylic acid
英文别名	更多

描述	CS-2100(化合物10b)是一种有效、选择性、口服活性和S1P3保留的S1P1激动剂,对人S1P1的EC50为4.0 nM。CS-2100对HvGR的ID50(感染剂量)为0.407 mg/kg的大鼠显示出体内免疫抑制效果【1】。
相关类别	信号通路 >> G 蛋白偶联受体/G 蛋白 >> LPL受体研究领域 >> 炎症/免疫
靶点	EC50: 4.0 nM (human S1P1)[1]
参考文献	[1]. Nakamura T, et al. Discovery of CS-2100, a potent, orally active and S1P3-sparing S1P1 agonist. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1788-92.

分子式	C₂₅H₂₃N₃O₄S
分子量	461.53
精确质量	461.14100
PSA	116.93000
LogP	5.27410
InChIKey	DWVJASHDNJMDNH-UHFFFAOYSA-N
SMILES	CCc1cc(CN2CC(C(=O)O)C2)sc1-c1noc(-c2ccc(Oc3ccccc3)cc2)n1

5-({[tert-butyl(dimethyl)silyl]oxy}methyl)-3-ethylthiophene-2-carboxaldehyde结构式

5-({[tert-butyl...

913828-81-6

~%

CS 2100结构式

CS 2100

913827-99-3

文献：Nakamura, Tsuyoshi; Asano, Masayoshi; Sekiguchi, Yukiko; Mizuno, Yumiko; Tamaki, Kazuhiko; Nara, Futoshi; Kawase, Yumi; Yabe, Yoshiyuki; Nakai, Daisuke; Kamiyama, Emi; Urasaki-Kaneno, Yoko; Shimozato, Takaichi; Doi-Komuro, Hiromi; Kagari, Takashi; Tomisato, Wataru; Inoue, Ryotaku; Nagasaki, Miyuki; Yuita, Hiroshi; Oguchi-Oshima, Keiko; Kaneko, Reina; Nishi, Takahide European Journal of Medicinal Chemistry, 2012 , vol. 51, p. 92 - 98

5-(((tert-butyldimethylsilyl)oxy)methyl)-3-ethylthiophene-2-carbaldehyde oxime结构式

5-(((tert-butyl...

1028947-14-9

~%

CS 2100结构式

CS 2100

913827-99-3

文献：Nakamura, Tsuyoshi; Asano, Masayoshi; Sekiguchi, Yukiko; Mizuno, Yumiko; Tamaki, Kazuhiko; Nara, Futoshi; Kawase, Yumi; Yabe, Yoshiyuki; Nakai, Daisuke; Kamiyama, Emi; Urasaki-Kaneno, Yoko; Shimozato, Takaichi; Doi-Komuro, Hiromi; Kagari, Takashi; Tomisato, Wataru; Inoue, Ryotaku; Nagasaki, Miyuki; Yuita, Hiroshi; Oguchi-Oshima, Keiko; Kaneko, Reina; Nishi, Takahide European Journal of Medicinal Chemistry, 2012 , vol. 51, p. 92 - 98

5-({[tert-butyl(dimethyl)silyl]oxy}methyl)-3-ethylthiophene-2-carbonitrile结构式

5-({[tert-butyl...

913828-82-7

~%

CS 2100结构式

CS 2100

913827-99-3

文献：Nakamura, Tsuyoshi; Asano, Masayoshi; Sekiguchi, Yukiko; Mizuno, Yumiko; Tamaki, Kazuhiko; Nara, Futoshi; Kawase, Yumi; Yabe, Yoshiyuki; Nakai, Daisuke; Kamiyama, Emi; Urasaki-Kaneno, Yoko; Shimozato, Takaichi; Doi-Komuro, Hiromi; Kagari, Takashi; Tomisato, Wataru; Inoue, Ryotaku; Nagasaki, Miyuki; Yuita, Hiroshi; Oguchi-Oshima, Keiko; Kaneko, Reina; Nishi, Takahide European Journal of Medicinal Chemistry, 2012 , vol. 51, p. 92 - 98

5-({[tert-butyl(dimethyl)silyl]oxy}methyl)-3-ethyl-N'-hydroxythiophene-2-carboximidamide结构式

5-({[tert-butyl...

913828-83-8

~%

CS 2100结构式

CS 2100

913827-99-3

文献：Nakamura, Tsuyoshi; Asano, Masayoshi; Sekiguchi, Yukiko; Mizuno, Yumiko; Tamaki, Kazuhiko; Nara, Futoshi; Kawase, Yumi; Yabe, Yoshiyuki; Nakai, Daisuke; Kamiyama, Emi; Urasaki-Kaneno, Yoko; Shimozato, Takaichi; Doi-Komuro, Hiromi; Kagari, Takashi; Tomisato, Wataru; Inoue, Ryotaku; Nagasaki, Miyuki; Yuita, Hiroshi; Oguchi-Oshima, Keiko; Kaneko, Reina; Nishi, Takahide European Journal of Medicinal Chemistry, 2012 , vol. 51, p. 92 - 98

tert-butyl[(4-ethyl-2-thienyl)methoxy]dimethylsilane结构式

tert-butyl[(4-e...

913828-80-5

~%

CS 2100结构式

CS 2100

913827-99-3

文献：Nakamura, Tsuyoshi; Asano, Masayoshi; Sekiguchi, Yukiko; Mizuno, Yumiko; Tamaki, Kazuhiko; Nara, Futoshi; Kawase, Yumi; Yabe, Yoshiyuki; Nakai, Daisuke; Kamiyama, Emi; Urasaki-Kaneno, Yoko; Shimozato, Takaichi; Doi-Komuro, Hiromi; Kagari, Takashi; Tomisato, Wataru; Inoue, Ryotaku; Nagasaki, Miyuki; Yuita, Hiroshi; Oguchi-Oshima, Keiko; Kaneko, Reina; Nishi, Takahide European Journal of Medicinal Chemistry, 2012 , vol. 51, p. 92 - 98

(4-bromo-thiophene-2-ylmethoxy)-tert-butyl-dimethylsilane结构式

(4-bromo-thioph...

230623-72-0

~%

CS 2100结构式

CS 2100

913827-99-3

文献：Nakamura, Tsuyoshi; Asano, Masayoshi; Sekiguchi, Yukiko; Mizuno, Yumiko; Tamaki, Kazuhiko; Nara, Futoshi; Kawase, Yumi; Yabe, Yoshiyuki; Nakai, Daisuke; Kamiyama, Emi; Urasaki-Kaneno, Yoko; Shimozato, Takaichi; Doi-Komuro, Hiromi; Kagari, Takashi; Tomisato, Wataru; Inoue, Ryotaku; Nagasaki, Miyuki; Yuita, Hiroshi; Oguchi-Oshima, Keiko; Kaneko, Reina; Nishi, Takahide European Journal of Medicinal Chemistry, 2012 , vol. 51, p. 92 - 98

1-({4-[1-(3-oxo-3-phenyl-propyl)-1H-benzoimidazol-2-ylmethyl]-piperazin-1-yl}-acetyl)-pyrrolidine

1-({4-ethyl-5-[5-(4-phenoxyphenyl)-1,2,4-oxadiazol-3-yl]-2-thienyl}methyl)azetidine-3-carboxylic acid

Pyrrolidine,1-((4-((1-(3-oxo-3-phenylpropyl)-1H-benzimidazol-2-yl)methyl)-1-piperazinyl)acetyl)

1-(2'-Benzoyleth-1'-yl)-2-(4''-pyrrolidinocarbonylmethylpiperazine-1''-ylmethyl)benzimidazole

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上海阿拉丁生化科技股份有限公司
上海市上海市浦东新区
产品名：CS 2100
产品网址：http://www.aladdin-e.com/zh_cn/C288870.html
纯度：97.0%
价格：￥10500.0/50mg ￥需询单/1g ￥需询单/1g ￥需询单/1g
联系人：阿拉丁
联系电话：400-620-6333
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