Tetrahedron

First synthesis of a steroid containing an unstable 19-nor-androsta-1, 5-dien-3-one system

C Cadot, D Poirier, A Philip

文献索引：Cadot, Christine; Poirier, Donald; Philip, Anie Tetrahedron, 2006 , vol. 62, # 18 p. 4384 - 4392

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被引用次数: 6

摘要

Mechanisms involved in the maintenance of human pregnancy and initiation of labour are poorly defined. A novel steroid hormone named estradienolone (ED), and having an unusual 19-nor-androsta-1, 5-dien-3-one system, was previously reported. However, ED is scarcely available from urine, placenta and blood of pregnant women. For this reason, we have synthesized ED in order to verify its proposed structure. Although a 1, 5-dien-3-one ...