New synthesis of estradiol from androsta-1, 4-diene-3, 17-dione

…, DM Kochev, MA Lapitskaya, KK Pivnitsky

文献索引：Vasiljeva; Demin; Kochev; Lapitskaya; Pivnitsky Russian Chemical Bulletin, 1999 , vol. 48, # 3 p. 593 - 595

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被引用次数: 2

摘要

Abstract A new method for the aromatization of ring A in androsta-1, 4-diene-3, 17-dione, available from sterols by means of the microbiological degradation of the side chain, was developed. The method consists of the reduction of androsta-1, 4-diene-3, 17-dione to the corresponding dienediol followed by double C, O-deprotonation of ring A, accompanied by expulsion of the 19-methyl group and formation of estradiol in a high yield.