Product inhibition and dose??dependent bioavailability of propranolol in the isolated perfused rat liver preparation

…, CK Stead, RA Smallwood, DJ Morgan

文献索引：Ghabrial; Nand; Stead; Smallwood; Morgan Journal of Pharmaceutical Sciences, 1994 , vol. 83, # 7 p. 931 - 936

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被引用次数: 3

摘要

Abstract We investigated in the isolated perfused rat liver (IPRL) whether product inhibition of metabolism contributes to the dose-dependent bioavailability of propranolol, a drug with a high, but saturable, hepatic first-pass effect.(±)-Propranolol was infused in the IPRL, using a recirculating design, for three 36-min periods (n= 9). Mean steady-state reservoir, ie hepatic inflow concentrations (C in), were 4.97, 10.4, and 20.4 μM, respectively. Mean reservoir ...