Covalent binding of a reactive metabolite derived from propranolol and its active metabolite 4-hydroxypropranolol to hepatic microsomal proteins of the rat

…, T Horie, T Suzuki, T Ishikawa, M Tsutsui…

文献索引：Narimatsu, Shizuo; Arai, Takayuki; Watanabe, Toshiyuki; Masubuchi, Yasuhiro; Horie, Toshiharu; Suzuki, Tokuji; Ishikawa, Tsutomu; Tsutsui, Michio; Kumagai, Yoshito; Cho, Arthur K. Chemical Research in Toxicology, 1997 , vol. 10, # 3 p. 289 - 295

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被引用次数: 25

摘要

Repeated administration of propranolol (PL) to rats causes the inhibition of cytochrome P450-2D (P450-2D) enzyme. We recently found that 4-hydroxypropranolol (4-OH-PL) was biotransformed to 1, 4-naphthoquinone (1, 4-NQ) by superoxide (SO) anions in medium containing rat liver microsomes and NADPH and proposed that the binding of the quinone to P450-2D apoproteins might be one of mechanisms for the enzyme inhibition [Narimatsu et ...