Ring-hydroxylated propranolol: synthesis and. beta.-receptor antagonist and vasodilating activities of the seven isomers

JE Oatis Jr, MP Russell, DR Knapp…

文献索引：Oatis Jr.; Russell; Knapp; Walle Journal of Medicinal Chemistry, 1981 , vol. 24, # 3 p. 309 - 314

被引用次数: 70

摘要

Chemistry. 2 '-Hydroxy-, 4'-Hydroxy-, 5 '-Hydroxy-, 6'-Hydroxy-, and 7'-Hydroxypropranolol (la, cf). Five of the isomers of hydroxypropranolol were prepared from the corresponding methoxynaphthols (h, cf) by the route shown in Scheme I. Compound 2a was prepared from 2-methoxy-1-naphthaldehyde (5, Scheme 11) via a Baeyer-Villigerl'rearrangement using m- chloroperbenzoic acid to form 6, which upon hydrolysis with aqueous sodium hydroxide ...

18507-09-0

4-甲氧基普萘洛尔

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