Tetrahedron letters

Monohalomethyllithium XCH2Li: stabilization of a potential synthetic reagent

R Tarhouni, B Kirschleger, M Rambaud, J Villieras

文献索引：Tarhouni, R.; Kirschleger, B.; Rambaud, M.; Villieras, J. Tetrahedron Letters, 1984 , vol. 25, # 8 p. 835 - 838

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被引用次数: 73

摘要

Abstract The preparation of monohalomethyllithium XCH 2 Li is achieved by Bromine-lithium exchange from the corresponding Bromohalomethane in the presence of one equivalent of lithium bromide at− 110 in THF-Ether-Pentane solutions. This reagent, on coupling with various carbonyl compounds leads to halohydrins, epoxides and α-halomethyl ketones with high yields.