2-(4-Chlorobenzyl)-3-hydroxy-7, 8, 9, 10-tetrahydrobenzo [H] quinoline-4-carboxylic acid (PSI-697): identification of a clinical candidate from the quinoline salicylic …

N Kaila, K Janz, A Huang, A Moretto…

文献索引：Journal of Medicinal Chemistry, , vol. 50, # 1 p. 40 - 64

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被引用次数: 73

摘要

... Journal of Medicinal Chemistry. ... Chemistry. The target quinolines (2) were synthesized using the Pfitzinger reaction between an isatin (3) and an α-keto acetate (4), as described previously (Scheme 1). 25,31 The isatins ...