Organic letters

Continuous flow generation and reactions of anhydrous diazomethane using a Teflon AF-2400 tube-in-tube reactor

F Mastronardi, B Gutmann, CO Kappe

文献索引：Mastronardi, Federica; Gutmann, Bernhard; Oliver Kappe Organic Letters, 2013 , vol. 15, # 21 p. 5590 - 5593

全文：HTML全文

被引用次数: 56

摘要

A continuous process for generation, separation, and reactions of anhydrous diazomethane in a tube-in-tube reactor was developed. The inner tube of the reactor is made of hydrophobic, gas-permeable Teflon AF-2400. The diazomethane is formed in the inner tube and then diffuses through the permeable membrane into the outer chamber and subsequently reacts in the solution carried within. This technique allows safe and scalable ...