Angewandte Chemie International Edition

No Contribution of an Inductive Effect to Secondary Deuterium Isotope Effects on Acidity

CL Perrin, A Flach

文献索引：Perrin, Charles L.; Flach, Agnes Angewandte Chemie - International Edition, 2011 , vol. 50, # 33 p. 7674 - 7676

全文：HTML全文

被引用次数: 16

摘要

Isotope effects are observed when a reaction rate or equilibrium constant changes as a result of isotopic substitution.[1] They continue to be used as valuable tools to provide insight into molecular structure and reactivity.[2] Secondary isotope effects are those in which the bond to the isotope remains intact. Their origin continues to be an area of investigation.[3] Herein we address the origin of secondary deuterium isotope effects on acidity. Deuterium ...