Isotope effects are observed when a reaction rate or equilibrium constant changes as a result of isotopic substitution.[1] They continue to be used as valuable tools to provide insight into molecular structure and reactivity.[2] Secondary isotope effects are those in which the bond to the isotope remains intact. Their origin continues to be an area of investigation.[3] Herein we address the origin of secondary deuterium isotope effects on acidity. Deuterium ...
[Bartholomew, Richard J.; Stevenson, Wendy J.; Irish, Donald E. Spectrochimica Acta - Part A Molecular Spectroscopy, 1996 , vol. 52, # 13 p. 1695 - 1701]
