Enzyme-catalyzed organic synthesis: regeneration of deuterated nicotinamide cofactors for use in large-scale enzymatic synthesis of deuterated substances

CH Wong, GM Whitesides

文献索引：Wong; Whitesides Journal of the American Chemical Society, 1983 , vol. 105, # 15 p. 5012 - 5014

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被引用次数: 42

摘要

Abstract: We have developed procedures for in situ regeneration of deuterated nicotinamide cofactors based on ethanol-1, l,-d2/alcohol dehydrogenase/aldehyde dehydrogenase, deuterioformate (DC02-)/formate dehydrogenase, and glycolaldehyde-1, 2, 2-d3/aldehyde dehydrogenase. These procedures can be used in the enzyme-catalyzed synthesis of deuterated organic products; representative procedures are illustrated by syntheses of (R) ...