Tetrahydronaphthalene Derivatives by Amberlyst® 15-Promoted Friedel-Crafts Cyclizations

RA Bunce, AN Cox

文献索引：Bunce, Richard A.; Cox, Andrew N. Organic Preparations and Procedures International, 2010 , vol. 42, # 1 p. 83 - 93

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被引用次数: 4

摘要

A recent project required the preparation of a series of 1, 1-disubstituted-1, 2, 3, 4- tetrahydronaphthalene derivatives. These compounds are known to be both retinoic acid receptor (RAR) antagonists and retinoic X receptor (RXR) agonists. As RAR antagonists, these materials have been investigated for the treatment of dermatological diseases, such as psoriasis and eczema. 1 As RXR agonists, these agents have been co-administered ...