Protein tyrosine kinase inhibitory properties of planar polycyclics obtained from the marine sponge Xestospongia cf. carbonaria and from total synthesis

KA Alvi, J Rodriguez, MC Diaz, R Moretti…

文献索引：Alvi, Khisal A.; Rodriguez, Jaime; Diaz, Maria Cristina; Moretti, Robert; Wilhelm, Robert S.; et al. Journal of Organic Chemistry, 1993 , vol. 58, # 18 p. 4871 - 4880

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被引用次数: 60

摘要

Nine related polycyclic quinones and hydroquinones of the halenaquinone class were isolated from two Indo-Pacific collections of the sponge Xestospongia cf. carbonaria. The halenaquinone family appears not to be of polyketide origin but can be biogenetically derived by the union of a sesquiterpene and a quinone. Four new metabolites were characterized including tetrahydrohalenaquinone B@ a), 14-methoxyhalenaquinone (9), ...