Chemische Berichte

Direct geminal dimethylation of ketones and exhaustive methylation of carboxylic acid chlorides using dichlorodimethyltitanium

MT Reetz, J Westermann, SH Kyung

文献索引：Reetz, Manfred T.; Westermann, Juergen; Kyung, Suk-Hun Chemische Berichte, 1985 , vol. 118, # 3 p. 1050 - 1057

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被引用次数: 52

摘要

Abstract The reaction of ketones with an excess of (CH 3) 2 TiCl 2 (6) leads to the replacement of the carbonyl oxygen atom by two methyl groups. This mild method of direct geminal dimethylation involves Grignard-type addition followed by formation of tertiary carbocations which are captured by methyltitanium species. Additional functional groups such as primary alkyl chlorides, thioethers, aromatics, ethers, and esters are tolerated, but ...