The Journal of Organic Chemistry

Novel N-alkylation of amines with organocopper reagents

H Yamamoto, K Maruoka

文献索引：Yamamoto, Hisashi; Maruoka, Keiji Journal of Organic Chemistry, 1980 , vol. 45, # 13 p. 2739 - 2740

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被引用次数: 82

摘要

Summary: A mild and efficient method for the N-alkylation of amines is described, based on the oxidative coupling of lithium alkylcopper amide, which is derived from lithium dialkylcuprates and primary or secondary amines. The high chemospecificity of the method was demonstrated.