The Journal of organic chemistry

Catalytic reductive alkylation of secondary amine with aldehyde and silane by an iridium compound

T Mizuta, S Sakaguchi, Y Ishii

文献索引：Mizuta, Tomoya; Sakaguchi, Satoshi; Ishii, Yasutaka Journal of Organic Chemistry, 2005 , vol. 70, # 6 p. 2195 - 2199

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被引用次数: 90

摘要

An efficient methodology for the reductive alkylation of secondary amine with aldehyde and Et3SiH using an iridium complex as a catalyst has been developed. For example, treatment of dibutylamine with butyraldehyde and Et3SiH (a 1: 1: 1 molar amount of amine, aldehyde, and silane) in 1, 4-dioxane at 75° C under the influence of a catalytic amount of [IrCl (cod)] 2 gave tributylamine in quantitative yield. In this reaction, no reduction of aldehyde took ...