Tetrahedron: Asymmetry

Enzymatic dynamic kinetic resolution of epihalohydrins

JHL Spelberg, L Tang, RM Kellogg, DB Janssen

文献索引：Lutje Spelberg, Jeffrey H.; Tang, Lixia; Kellogg, Richard M.; Janssen, Dick B. Tetrahedron Asymmetry, 2004 , vol. 15, # 7 p. 1095 - 1102

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被引用次数: 46

摘要

The haloalcohol dehalogenase from Agrobacterium radiobacter AD1 catalyses the reversible ring closure of vicinal haloalcohols to produce epoxides and halides. In the ring opening of epoxides, nonhalide nucleophiles such as N3− are accepted. The enantioselective irreversible ring opening of an epihalohydrin by N3−, combined with racemisation caused by a reversible ring opening by a halide, resulted in an enzymatic ...